Protein Biochemist
- Employer
- Terray Therapeutics
- Location
- Pasadena, CA, United States
- Start date
- Nov 10, 2020
View more
- Discipline
- Science/R&D, Bioengineering
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Beach
Job Details
Position Summary: Terray Therapeutics is seeking a motivated, creative, and experienced protein biochemist. As an integral member of our biology group, the candidate will be responsible for expression, purification, labelling and analytical characterization of protein targets for use in our affinity screens. The position will report to the Head of Biology.
The core responsibilities of this job will be
- Identify and design appropriate protein constructs for screening on Terray's small molecule arrays
- Oversee protein expression and purification efforts at external CROs for a broad range of protein targets
- Perform analytical characterization and labelling of protein preparations
- Establish protein expression and purification capabilities at Terray as needed
- Potential to be involved in the development and execution of high through-put biochemical, enzymatic and/or protein interaction assays to evaluate hits from affinity screens
Experience and Qualifications: Given the company's size, anticipated growth and fast-paced environment, the organization requires a Scientist who is thoughtful, high energy and can partner with the broader organization to further enhance our next generation drug discovery capabilities.
Part of Terray Therapeutics' success is nurtured by a hands-on work environment where everyone is accountable, everyone is vested in a vision of excellence, and everyone actively takes part in the success of the business. Terray Therapeutics supports a positive work environment comprised of engaged employees who feel appreciated, recognized and free to be creative.
Qualifications include:
- PhD in the field of protein biochemistry, enzymology and/or structural biology
- 5+ years of hands-on experience in protein synthesis, purification and modification
- Broad experience in expressing recombinant proteins in a variety of expression systems and modern molecular cloning techniques
- Extensive hands-on experience in protein purification using a variety of chromatographic techniques
- Experience in use of analytical/biophysical techniques (HPLC, DLS, DSF, etc.) for assessing stability, solubility, and oligomerization status of proteins
- Experience in structural biology (X-ray crystallography, NMR, Cryo-EM) highly desired
- Experience with enzymology, protein-protein interaction and/or DNA/RNA-binding proteins would be a plus
- Demonstrated technical proficiency, ability to troubleshoot to solve problems and to deliver high quality data
She/he will exhibit the ability to work well under pressure to provide results in a short timeframe. The company is looking for a highly responsive, goal-oriented individual who will bring significant energy and drive to solve complex technical problems and help us achieve our mission to advance human health.
Company
Terray is a biotechnology company with the technology, data, and mindset to radically change the way we discover and develop small molecule therapeutics. We explore molecules and targets broadly and deeply with a sophisticated integration of ultra-high throughput experimentation, generative AI, biology, medicinal chemistry, automation, and nanotechnology. Everything the company does is grounded in an iterative approach, producing massive amounts of precise, purpose-built data that gets increasingly valuable with each cycle of design and experimentation. The company’s platform uniquely blends experimentation and computation to improve the cost, speed, and success rate of small molecule drug discovery and development.
- Website
- http://www.terraytx.com/
- Location
-
750 Royal Oaks, Suite 100
Monrovia
CA
91016
United States
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