Scientist, Cell Differentiation

Location
Cambridge
Posted
Nov 10, 2020
Ref
4925686002
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time
JOB PURPOSE

We are seeking a passionate and detail-oriented laboratory scientist with experience in mammalian or pluripotent stem cell culture to join a growing cell differentiation team. Under the supervision of a Senior Director, the scientist will be responsible for daily tasks involving the growth, differentiation, and characterization of pluripotent stem cells in scalable 3D differentiation models to support a cell-based therapeutic program. This role will establish the methods and parameters for scaling a cell therapeutic product to support preclinical studies, and work closely with the cell manufacturing team to adapt the methods for clinical scale.

DUTIES AND RESPONSIBILITIES
  1. Culture and differentiation of pluripotent stem cells.
  2. Optimization of differentiation of 3D spheroids in various suspension models to support scaling of cell therapeutic product.
  3. Analysis of differentiated cell products (Flow cytometry, PCR, fluorescent microscopy, etc) and establishment of QC metrics.
  4. Participate in the planning, design and execution of experiments.
  5. Make observations, interpret results and document experimental methods in a well-maintained laboratory notebook.
  6. Coordinate with other team members as necessary to ensure the completion of the team's research projects.
  7. Comply with standard laboratory practices and company policies.

QUALIFICATIONS
  • BA or MS degree with 7+ years of laboratory experience, or PhD with 2+ years in a relevant scientific discipline.
  • Demonstrated expertise in 3D cell culture within scaled vessels such as spinner or shaker flasks.
  • Prior experience with mammalian cell culture is required; experience with pluripotent cell culture is preferred.
  • Ability to collaboratively work with scientists in a cross-functional or matrixed team environment.