Assay Scientist

South San Francisco, South CA, South United States
Nov 09, 2020
Biotech Bay
Required Education
Position Type
Full time

Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14 and CasPhi, Mammoth Biosciences can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Mammoth is democratizing disease detection with easy and affordable point-of-care tests that allow real-time and simultaneous detection of multiple conditions, along with high-throughput tests that allow for unprecedented testing volume. Further, the company is transforming disease treatment with its proprietary micro-sized CRISPR proteins that enable new editing and delivery options. Based in San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX, and 8VC, and leading individual investors including Brook Byers, Tim Cook, Bob Nelsen, and Jeff Huber.


Mammoth is seeking a Scientist with expertise in protein and nucleic acid biochemistry techniques. As part of the product development team, the ideal candidate will have experiences with assay development and product commercialization related to molecular tests and reagent kits. Further, the candidate will be comfortable leading, managing and collaborating across the team as needed, with demonstrated ability to prioritize projects, agendas and time to accomplish assigned goals.

    • Plan, design and execute experiments for CRISPR based, high-throughput, automated diagnostic assay optimization; and CRISPR reagent formulation development and stability
    • Analyze data, evaluate results, form conclusions, and provide and/or implement improvements; communicate results with colleagues and management
    • Lead the development and implementation of quality control procedures for critical reagents, processes and instruments
    • Optimize and ensure product performance by utilizing proven development practices and/or developing novel procedures
    • Optimize and document SOPs to achieve commercial levels of stability, robustness and performance
    • Coordinate with third party manufacturer and conduct technology transfer

    • Ph.D. in Biochemistry, Molecular Biology, or related field with 3 years of industry experience, or MSc with 5 years of experience
    • Strong background in assay development and product commercialization
    • Experience with reagent formulation development
    • Experience with DOE methodologies
    • Experience with Design Control and working within the Quality Management System

    • Experience with Diagnostics test development
    • Experience with integration of molecular assay onto automation platforms
    • Experience with CRISPR technology
    • Strong communication, presentation and data analysis skills
    • Highly motivated and detail-oriented individual with the ability to think creatively

    • Competitive salary with equity
    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Free breakfast/lunch/dinner/barista
    • Free gym
    • Public transportation commuter subsidy
    • 401(k) matching