AbbVie

Sr Scientist I/II, Drug Transporter - DMPK - BA

Employer
AbbVie
Location
Sunnyvale, CA, United States
Posted
Nov 08, 2020
Ref
2007494
Required Education
Doctorate/PHD/MD
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

General Position Summary/Purpose:

The DMPK-BA department in Sunnyvale, CA is seeking a highly motivated Transporter Scientist to join the In Vitro ADME group. The successful candidate will work in collaboration with other team members to characterize the absorption, distribution, metabolism and excretion of candidate drug molecules. DMPK-BA works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.

In this role, you will be an expert in drug transporters with experience in conducting and optimizing preclinical invitro assays to evaluate candidate drug molecules as inhibitors or substrates of uptake transporters, as well as conducting hepatocyte uptake assays. Furthermore you will serve as subject matter expert in drug transporter sciences, keeping up to date with the literature in this field, and providing support to project teams to enhance our mechanistic understanding of the "complex interplay" between drug transporters and drug metabolizing enzymes, and how this affects drug disposition/interaction.

Key Accountabilities/Core Job Responsibilities:
  • Capable of performing substrate/inhibitor kinetics for uptake transporters
  • Working knowledge of drug transporter sciences, and capable of performing and interpreting in vitro drug transporter studies in recombinant cell lines or hepatocytes.
  • Knowledge of in vitro ADME assays
  • Capable of using in vitro and in silico tools to support the prediction of transporter-mediated pharmacokinetics (PK) and drug interactions (DDIs) in humans
  • Extensive experience in cell culture
  • Has knowledge of both biological and physicochemical properties of small molecules that influence drug disposition
  • Maintain knowledge of state-of-the art principles and theories in ADME and uptake transporter sciences (in particular).
  • Serve as in-house expert in uptake transporter sciences.
  • Ability to clearly communicate, interact with and influence others, acts as a mentor, trainer or coach.
  • Interprets findings, writes reports and makes presentations at internal cross-functional teams as well as external conferences
  • Closely follows primary literature to maintain awareness

Qualifications

Qualifications
Education, Qualifications and Experience Requirements (degree, certifications, etc.):

  • PhD degree (4 years of experience), MS degree (10 years of experience), B.S. (12 years of experience), or equivalent in drug metabolism or related discipline with relevant industry experience in drug discovery/development
  • Prior experience with drug transporters is required.
  • The candidate must be able to analyze data and maintain detailed, accurate and comprehensible study documentation. Experience with use of electronic notebook is a plus
  • The individual is also expected to be organized, a team player, passionate about drug discovery, and possess effective communication skills

Significant Work Activities
Awkward/forceful/repetitive motions (arms above shoulders, bent wrists, etc.)
Travel
Yes, 5 % of the Time
Job Type
Experienced
Schedule
Full-time
Job Level Code
M
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.