Scientist / Associate Scientist, Cancer Immunotherapy

Location
San Diego, CA, United States
Posted
Nov 07, 2020
Ref
414BY
Hotbed
Biotech Beach
Required Education
Doctorate/PHD/MD
Position Type
Full time
Fate Therapeutics is seeking a highly motivated scientist/associate scientist specialized in immunology
and immunotherapy to participate in the discovery of next-generation off-the-shelf induced pluripotent
stem cell (iPSC)-derived CAR-T (CAR-iT) cell therapeutic products. The successful candidate will leverage
Fate's best-in-class iPSC platform to develop and investigate novel modalities to enhance CAR-iT cell
performance in vitro and in vivo and will conduct such activities in collaboration with multiple internal
and external groups, including academic leaders in the field of immunotherapy. Prior independent
research experience with T cell development, T cell signal transduction or cancer immunotherapy is
highly preferred. This is a full-time bench-level position reporting to a Scientist and is located at our
corporate headquarters in San Diego, CA.

Responsibilities
• Differentiate and evaluate off-the-shelf, iPSC-derived CART cells with in vitro assays (including
cytokine release/degranulation and short/long-term killing assay and RNA-seq) and in vivo
murine models.
• Investigate, develop and implement novel strategies for next-generation off-the-shelf CAR-iT cell
discovery.
• Plan, coordinate and conduct original and independent research with precise data analysis,
interpretation, and communication capability and deliver results in a timely manner.
• Participate in daily laboratory maintenance activities including ordering and maintaining stocks
of lab reagents.
• Present results in a multidisciplinary team environment that includes collaborations with top
research laboratories and pharmaceutical companies.

Qualifications
• PhD degree in Immunology, Cancer Biology, Cell Biology or related fields with 0-2 years of
relevant experience, or M.S. degree in Biology or related fields with 4+ years relevant
experience, or B.S. degree in Biology or related fields with 8+ years of years relevant experience,
preferably in a biotech setting.
• Proven track record of leading or contributing to projects in immunology, cancer biology or cell
biology.
• In-depth experience with multi-parameter flow cytometry is a must, preferably 8+ color.
• Extensive aseptic technique and mammalian cell culture experience with a minimal of 3 years of
hands-on experience is a must.
• Positive outlook, willingness to learn and contribute, and a team-oriented attitude is a must.
• Experience with immune cell functional assays and gene editing of T cells by transfection or
transduction is a plus.
• Experience with human CAR-T cells is a plus.
• Knowledge on T cell development, T cell signal transduction, or cellular immunotherapy in
oncology is a plus.
• Knowledge with single-cell RNA-seq analysis and bulk RNA-seq analysis is a plus.

Working Conditions and Physical Requirements
• Will require working with cells and cell lines of human and/or animal origin
• Will require working with hazardous materials
• 100% on-site work at corporate headquarters in San Diego, CA
• Evening and weekend work as necessary

The preceding job description indicates the general nature and level of work performed by
employees within this classification. Additional and incidental duties related to the primary duties
may be required from time to time.

For consideration send cover letter and resume to: careers@fatetherapeutics.com and reference
job code 414BY.

About Fate Therapeutics, Inc.
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of
first-in-class cellular immunotherapies for cancer and immune disorders. The Company has
established a leadership position in the clinical development and manufacture of universal, off-the-
shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The
Company's immuno-oncology product candidates include natural killer (NK) cell and T-cell cancer
immunotherapies, which are designed to synergize with well-established cancer therapies, including
immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens
with chimeric antigen receptors (CARs). The Company's immuno-regulatory product candidates
include ProTmune™, a pharmacologically modulated, donor cell graft that is currently being
evaluated in a Phase 2 clinical trial for the prevention of graft-versus-host disease, and a myeloid-
derived suppressor cell immunotherapy for promoting immune tolerance in patients with immune
disorders. Fate Therapeutics is headquartered in San Diego, CA. For more information, please
visit www.fatetherapeutics.com.