Research Associate / Senior Research Associate

Employer
Nkarta Inc
Location
South San Francisco, CA, United States
Posted
Nov 07, 2020
Ref
25468
Discipline
Science/R&D, Research
Hotbed
Biotech Bay
Required Education
Associate Degree
Position Type
Full time
Research Associate / Senior Research Associate

Nkarta is a clinical-stage biotechnology company advancing the development of allogeneic, off the shelf natural killer (NK) cell therapies for cancer. By combining its cell expansion and cryopreservation platform with proprietary cell engineering technologies, Nkarta is building a pipeline of cell therapy candidates generated by efficient manufacturing processes, which are engineered to enhance tumor targeting and improve persistence for sustained activity in the body.

Founded in 2015 at the birthplace of biotechnology in South San Francisco, CA, Nkarta became a public company (Nasdaq symbol NKTX) in 2020. Our development pipeline of engineered NK cell therapy candidates consists of co-lead programs, NKX101 and NKX019. The IND for NKX101 for the treatment of relapsed or refractory AML and higher-risk MDS was accepted by the FDA in July 2020. Patient dosing began in Q4 2020. As we broaden the development of NKX101, we also plan to initiate studies in solid tumors. Our second co-lead program, NKX019, is designed to target B cell lymphomas. We plan to file our IND for NKX019 with the FDA in early 2021.

Position Title Research Associate / Senior RA

Location South San Francisco, CA

Reports to Staff Scientist, Research

Position Summary

We are seeking a highly motivated Research Associate/Senior Research Associate to join our early discovery and development team. The ideal candidate will interact closely with group leaders, scientists and research associate to drive discovery and development of new therapeutics to pre-clinical development

Key Responsibilities

Cultures mammalian tissue, including isolation and culture of primary human cells from whole blood.

Provides support for NK expansion and downstream characterization of NK functions via flow-based and IncuCyte cytotoxicity assays, cytokine release and proliferation testing.

Performs studies utilizing cellular immunology to develop and analyze in vitro cell-based assays to support early discovery efforts and pipeline.

Performs immune phenotyping of cultured immune cells using multi-color FACs.

Analyzes and presents scientific results in team meetings.

Position Requirements

Experience with tissue culture of cell lines is required and experience with culture of primary immune cells and primary tumor tissue is preferred.

In-depth experience with in vitro cellular/immune/tumor biology would be a plus and ability to work in a fast-paced startup environment.

Demonstrated to work on complex problems where analysis requires an evaluation of multiple factors.

Ability to routinely exercise independent judgment in performing experimental methods, techniques, evaluation criteria for obtaining results, and data analysis.

Strong verbal and written skills for documentation of data, drafting of technical reports, and communication of progress to supervisor and project teams.

Ability to communicate and multi-task within a fast-paced team environment with a high degree of self-motivation and organization.

Strong ability to work successfully in a collaborative team environment.

Embodies the Nkarta culture of empowerment, diversity, and inclusion.

Education / Background

BSc or MSc in molecular biology, immunology or cell biology.

2 years of working experience is preferred.

Work Environment / Physical Demands

This position requires the ability to occasionally lift and/or move up to 25 pounds. Specific vision abilities for this job include close vision, depth perception and ability to adjust focus and the ability to work in and around common laboratory equipment. The regular requirements of an office environment (computers, computer screens, workstations, etc.) apply when not working in or around a laboratory environment.

Working at Nkarta

The 90+ team members at our South San Francisco, California primary location describe working at Nkarta, along with opportunities for improvement, in some of the following ways:

" Work is interesting - lots of projects in the pipeline (so I don't have to worry about the one project failing). Leadership is open, straight forward."

"Smart, capable, nice people. People I work with day to day are enjoyable."

"Employee-centric."

"I like that the company is open minded with a (people) -(looking for) a set of skills that can grow (as opposed to thinking you have to have exactly what's in a job spec now) Things that broaden their (employees) skills and growth."

"Like any startup there are fires to put out; feel confident we have the people to control those fires."

"Diverse people from different backgrounds."

To learn more about our work at Nkarta and the career opportunities that will drive us forward to serve patients, please visit the company's website at https://www.nkartatx.com