Research Associate, PharmTox

Location
Cambridge
Posted
Nov 07, 2020
Ref
4913789002
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time
JOB PURPOSE

This position will report directly to a scientist in the In Vivo Pharmacology group within the Pharmacology and Toxicology organization. The successful candidate will possess a wide variety of in vivo study based skillsets required to understand and execute on studies across scientific programs. The successful candidate will have three primary responsibilities: (1) to execute in vivo studies to support gene and cell therapy research programs at Sana, (2) to run flow cytometry to support studies ongoing in IVP (3) to carry out cell and tissue preparation work related to in vivo studies. The position will also require consistently close communication and interaction with other members of the IVP team, as well as research groups at Sana. The role will provide opportunities for designing and presenting independent research studies.

DUTIES & RESPONSIBILITIES
  • Work closely with the Scientist and current in vivo coordinator to plan and execute in vivo studies in support of cross-functional groups
  • IV, IP, SC, injection proficiency
  • Dissection, tissue collection and processing for assays such as flow cytometry
  • Perform flow cytometry
  • Due diligence on data recording, analysis and reporting using proper software (e.g.Graphpad Prism, Softmouse, FlowJo), electronic notebook, and data storage room
  • Presentation of data to the team

QUALIFICATIONS

Required Qualifications
  • BS in biology or related discipline and 1+ years of relevant research experience
  • Experience in working with mice: handling, injections (IV, IP, SC), bleeding, dissections and tissue harvest
  • Proficiency with standard molecular biology and cell biology techniques: RNA isolation and reverse-transcription, qPCR, staining for Flow Cytometry, running Flow Cytometry independently
  • Hands-on experience with isolating and culturing mammalian cell lines and primary cells
  • Demonstrated competence in sterile cell culture technique
  • Demonstrated experience with relevant software: Microsoft Word, Excel, PowerPoint, Graphpad Prism, FlowJo software
  • Proven ability to troubleshoot technical and scientific issues
  • Strong interpersonal skills and adaptable communication style
  • Strong organizational, record keeping, and data documentation skills
  • Excellent oral and written communication skills, attention to detail and data quality, and experience working on diverse collaborative teams
  • Willingness to work under adverse situations (e.g. COVID 19)

Preferred Qualifications
  • BS or MS degree in immunology or hepatology
  • Experience with immune cell profiling using flow cytometry techniques
  • Experience developing in vitro and in vivo assays