Principal Research Associate, Analytical Development

Location
Seattle
Posted
Nov 06, 2020
Ref
1795
Hotbed
BioForest
Required Education
Associate Degree
Position Type
Full time
Good things are happening at Omeros!

Come join our Omeros CMC Team!

This position will support clinical development and commercialization of antibody therapeutics. The Principal Associate will bring a strong technical background including development, transfer, and qualification of analytical methods, characterizing physicochemical attributes of therapeutic candidates, developing new and orthogonal methods for extended characterization, and evaluating orthogonal and complimentary technologies to improve throughput. This position will also contribute to tech transfer to clinical and commercial stage CRO's/CMO's.

Who is Omeros?

True innovation requires the right people, and that's what we have at Omeros - smart, hard-working and creative individuals who collaborate and drive to achieve what has not yet been done. We see strength in diversity - diversity in thought, expertise and experience.

We have taken a similar approach in structuring our company. While many biotechs pursue a single therapeutic area or scientific platform, we are strategically building a deep and diverse pipeline of first-in-class small-molecule and antibody therapeutics. The strength of our scientific discoveries and exclusive intellectual property positions enable our pipeline programs to target highly promising receptors and enzymes that others have not been able to develop.

Although cutting across a wide and diverse range of disorders and therapeutic indications - some orphan, others large-market and many for which there are no approved treatments - all of our drugs on the market and in development target critical unmet needs to improve the lives of patients in meaningful ways.

What are your job responsibilities?

  • Analytical method development, testing, transfer, qualification, and validation
  • Troubleshoot typical method and equipment challenges
  • Write standard test methods, technical reports summarizing analytical data, and qualification / validation reports
  • Participate in cross-functional teams as a representative of the Analytical Development group
  • Assists in trouble-shooting CMC-related problems from CROs / CMOs
  • Assists in investigations involving data generated internally and by CROs / CMOs
  • Ensures laboratory equipment is calibrated and maintained in proper working order to enable compliance with relevant regulations.
  • Contribute to drafting regulatory submissions
  • BS or MS degree in Chemistry, Biochemistry, Biology, Analytical Chemistry, or a related field with 7+ years of biotechnology and/or pharmaceutical industry experience
  • Experience developing robust HPLC (SEC, RP, peptide map, CEX, etc.) and/or CE-based (CE-SDS, cIEF, icIEF) methods
  • Experience with troubleshooting and optimizing methods
  • Experience with routine lab equipment and methods, including preparing buffers, measuring pH, UV absorbance, quantifying particulates, etc.
  • Experience and proficiency with Waters Empower and/or Sciex 32 Karat software is highly desired
  • Experience with technology transfer to third parties is desired
  • Strong understanding of technical principles of chromatographic and/or electrophoretic methods
  • Demonstrated analytical, problem solving and multi-tasking capabilities
  • Capable of interpreting data and communicating and presenting results to peers and management
  • Demonstrated written and verbal communication skills with peers and management
  • Detail oriented, proactive, and self-motivated
  • Demonstrated ability to build and maintain positive and collaborative relationships with management and peers
  • Intermittent physical activity including bending, reaching, pushing, pulling, or lifting up to 20 lbs.
  • May encounter prolonged periods of sitting or standing
  • This position requires working around hazardous materials located within the building
If you have the experience, skills and knowledge we are seeking, we'd love to hear from you! This is an exciting opportunity for the right person!

Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to hr@omeros.com or contact Omeros, asking for Human Resources, at (206) 676-5000