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Project Manager, Early Stage Research

Employer
4D Molecular Therapeutics
Location
Emeryville, CA, United States
Start date
Nov 5, 2020

View more

Discipline
Regulatory, Research/Documentation, Science/R&D
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay

Job Details

4D Molecular Therapeutics (4DMT) is a gene therapy company with a transformative discovery platform— Therapeutic Vector Evolution —that enables our “disease first” approach to product discovery and development, thereby allowing us to customize our AAV vectors to target specific tissue types associated with the underlying disease.

4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers uniquely generous benefits, and provides challenging opportunities for career development. Join us in creating the ultimate gene therapy products to cure genetic diseases in children and adults. 4D Molecular Therapeutics, located in Emeryville, CA.

GENERAL SUMMARY:

The Project Manager (PM) will help manage the internal scientific teams within R&D and will work closely with the 4DMT Project Management Office (PMO). The PM will regularly interface with CMC, Alliance Management, and Business Development and will ensure communication needs are met across the different functional teams/departments. The PM will assist in driving timelines to meet corporate milestones by tracking scientific progress and identifying potential risks and opportunities. The role reports directly to the Senior Project Manager of Early Stage Research and is a member of the PM team.

RESPONSIBILITIES
  • Scientific Team Management: 40% of TIME
  • Support Early Stage Research teams in the planning and execution of research projects to enable efficient deliverable and milestone completion; map out and update associated Gantt charts and trackers regularly
  • Work in partnership with project and department leaders to help identify risks and opportunities, implement corrective strategies, and execute on the research project plan


  • Meeting Management: 30% of TIME
  • Organize and oversee project team meetings by preparing agendas, minutes, and action/decision logs, and ensuring appropriate and timely action item follow-up
  • Support external collaborations/partnerships and associated interactions (e.g. meetings, minutes, communications etc.) when necessary


  • PM Team: 20% of TIME
  • Work closely with scientists in the R&D and Translational teams while being a key member of the PMO
  • Manage research project communications and ensure that all stakeholders are informed on project activities and their status
  • Other Activities: 10% of TIME
  • Assist with tasks including shipping and tracking of biological samples, communicating to external CROs, and updating internal teams on deliverables
  • Liaise with cross-functional and functional teams/departments (CMC, Alliance Management, Business Development, Legal etc.) to resolve issues and achieve corporate goals


QUALIFICATIONS
  • Education:
  • BS, MS, or PhD in a biological science (molecular biology, cell biology, microbiology, bioengineering or related field preferred)
  • PMP Certification a plus


  • Experience:
  • 1-2 years of project management experience required
  • Prior experience in biotech or the pharmaceutical industry preferred
  • Previous interaction or participation in cross-functional teams and work in a scientific or clinical setting supporting drug development is desired
  • Gene therapy and/or rare disease experience a plus


  • Skills: (non-technical and technical skills)
  • Exceptional written, verbal, and organizational skills with a keen attention to detail
  • Proficient in relevant software: Excel, PowerPoint, Word, MS Project
  • Able to work independently and collaboratively; must be a team player focused on shared goals and successes
  • Exhibit strong interpersonal skills, a professional demeanor, and high emotional intelligence, with a demonstrated ability to build trust with colleagues across a team or organization
  • Comfortable with and motivated by a fast-paced, dynamic working environment


4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Company

4DMT is a gene therapy company with a transformative discovery platform --Therapeutic Vector Evolution --that enables our “disease first” approach to product discovery and development, thereby allowing us to customize our AAV vectors to target specific tissue types associated with the underlying disease.


At 4DMT we are creating and developing optimized “biopharmaceutical grade” AAV vectors that will allow us uniquely to unlock the full potential of gene therapy. Our customized and proprietary AAV vectors are each designed, according to a 4DMT Target Vector Profile, to deliver genes to specific cells and tissues in the body to eradicate both rare and large market diseases.


While AAV gene therapy pioneers are making great strides with the first wave of products, hurdles still exist with the use of conventional vectors. The most commonly used AAV capsids (e.g., AAV2, 5, 8 and 9) were identified either 1) as contaminants in lab stocks of adenovirus, or 2) through monkey tissue processing. Therefore, these conventional vectors are not targeted specifically to any tissue in the body. This can lead to inefficient and non-specific delivery, thus requiring extremely high doses and potentially resulting in toxicities (including inflammation), high manufacturing burdens and suboptimal efficacy. In addition, suboptimal routes of delivery can be required for delivery to the right tissues (e.g., subretinal delivery to the retina). Finally, pre-existing neutralizing antibodies in many patients can limit efficacy, clinical trial enrollment and market sizes. 4DMT Innovation empowers us to create new and improved next generation AAV capsids to allow targeted delivery of our products by the optimal clinical route of administration.


At 4DMT we use our robust discovery platform, termed “Therapeutic Vector Evolution,” to create customized and proprietary gene delivery vehicles (novel AAV vectors) to deliver genes to specific tissues and cells in the body by the optimal route of administration. We use the power of evolution to create and refine these optimized vectors through genetic diversification and then natural selection in vivo.


4D Purpose Statement:  Boldly Innovating to Unlock the Full Potential of Gene Therapy for Countless Patients


GUIDING PRINCIPLES

 

  • Dare to Cure - Patients are waiting. Create big dreams for patients and take calculated risks to achieve them
  • Break Boundaries - Question the status quo and innovate beyond conventional approaches
  • Beyond Yourself - It's about patients, their families, our team, our families. We strengthen each other.
  • Prepare and Execute Relentlessly - Start with the end in mind, over-prepare and make contingency plans to your contingency plans


We invite all of you who share our passion and vision in creating the ultimate gene therapy products to cure genetic and rare diseases in children and adults. We seek the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers generous benefits and provides challenging opportunities for career development. 
 

Company info
Website
Phone
510-505-2680
Location
5858 Horton St. Suite 455
Emeryville
California
94608
United States

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