Senior Scientist / Scientist, Process Development

Location
San Diego, CA, United States
Posted
Nov 03, 2020
Ref
425CC
Hotbed
Biotech Beach
Required Education
Doctorate/PHD/MD
Position Type
Full time
Fate Therapeutics is seeking a skilled and highly motivated cell biologist to join our company's Process Development team to support the company's off-the-shelf cellular immunotherapy programs. The successful candidate will be part of a multidisciplinary team
to develop robust and consistent manufacture process for iPSC derived NK cell (iNK) products. This role will be responsible to support preclinical activities including product characterization, process optimization, and pilot productions to identify key process parameters. This position requires prior experience in cellular therapy, process development, with proven records in optimizing mammalian cell culture and developing assays for immune cell characterization. Prior experience in cGMP environment is a plus. This is a full-time position and is located at our corporate headquarters in San Diego, CA.

Responsibilities:
• Design, perform and analyze complex multi-stage process parameters to identify critical
process parameters in iNK production.
• Evaluate or identify new method or technologies to monitor or control critical quality attributes from materials.
• Act as a subject matter expert from PD to collaborate with internal or external R&D, manufacturing, assay development and QC team for technology or method transfer.
• Train and supervise junior staffs in supporting CMC/IND related activities, including but
not limited to protocol driven study to support process change, pre-manufacture pilot production, and method qualification.
• Present data to Process and Assay Development team, Tech Ops group, and larger program-specific teams
• Management of reagent inventory and communication to relevant team members

Qualifications
• Ph.D in cell biology, immunology, bioengineering or closely related field with 5+ years of experience in biotech or pharmaceutical environment
• Extensive hands-on experience with iPSC/ESC culture and differentiation
• Prior experience in immunological techniques such as multi-color flow cytometry, cell-
based assay, cytokine detection, and single cell RNAseq
• Track record in process development of cellular therapy is highly desirable
• Prior experience in bioreactor or scale up cell culture is preferred
• Extensive knowledge in QbD, DOE, statistic data analysis is a plus
• Prior experience in transfer methods or process to cGMP manufacturing is a plus.
• Strong organization skills and ability to multitask
• Strong communication, writing, and presentation skills
• Ability to multi-task and work effectively in a dynamic and fast-paced setting
• Positive outlook, willingness to learn, and a desire to work collaboratively in a team environment

Working Conditions and Physical Requirements
• Will require working with cells and cell lines of human and/or animal origin
• Will require working with hazardous materials
• 100% on-site work at corporate headquarters in San Diego, CA
• Evening and weekend work as necessary
The preceding job description indicates the general nature and level of work performed by employees within this classification. Additional and incidental duties related to the primary duties may be required from time to time.
For consideration send cover letter and curriculum vitae to: careers@fatetherapeutics.com and reference Job Code 425CC.

About Fate Therapeutics, Inc.
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for cancer and immune disorders. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Company's immuno-oncology product candidates include natural killer (NK) cell and T-cell cancer immunotherapies, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens with chimeric antigen receptors (CARs). The Company's immuno-regulatory product candidates include ProTmune™, a pharmacologically modulated, donor cell graft that is currently being
evaluated in a Phase 2 clinical trial for the prevention of graft-versus-host disease, and a myeloid-derived suppressor cell immunotherapy for promoting immune tolerance in patients with immune disorders. Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit www.fatetherapeutics.com.