Clinical Biomarker Lead - Translational Science

Location
Hayward, CA, United States
Posted
Nov 03, 2020
Ref
152
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time
Arcus Biosciences is a clinical-stage company, with 4 compounds (2 antibodies and 2 small molecules) being evaluated across multiple clinical trials. Arcus also has a robust pipeline of preclinical and discovery programs that will continue to fuel the development pipeline. The recently announced multi-year broad collaboration with Gilead Sciences will greatly accelerate our clinical development activities and will create a unique professional opportunity for experienced individuals in all aspects of drug development, including translational science.

Overall description

We have an opening for a Biomarker Lead in a newly formed group with expertise in the development, execution and oversight of biomarker plans for assets in oncology clinical development. The Biomarker lead will be responsible for designing and implementing biomarker strategies for Arcus's clinical pipeline. The role requires demonstrated expertise in biomarker discovery, development, analysis and data interpretation with an ability to integrate scientific and disease specific contexts. The successful applicant will have the strong communication and leadership skills needed to build relationships with key stakeholders bridging research and development in a fast-paced environment.

Job duties and responsibilities include, but are not limited to:
  • Developing high quality translational strategies which may include patient selection, pharmacodynamic, mechanism of action/resistance, and other clinically relevant markers
  • Overseeing the execution of strategies and delivering biomarker results to internal and external stakeholders while working collaboratively with Biology, Clinical Science, Biometrics, Bioinformatics, Clinical Operations, and others
  • Leading cross functional biomarker teams providing expertise, driving decisions as well as enabling execution
  • Representing biomarker strategies at project teams, other review forums, and to external groups
  • Responsibility for authoring the biomarker sections of clinical protocols and regulatory documents

The chosen candidate will have a PhD, MD or equivalent in a relevant scientific field such as oncology or immunology. 5+ years of experience in clinical biomarker research at a drug development company is required in addition to:
  • Experience developing biomarker assays across a broad range of platform technologies (e.g. NGS, IHC, PCR, FISH, flow cytometry)
  • Excellent written and oral communication skills and ability to convey complex technical information clearly
  • Knowledge of companion diagnostic development preferred