Senior Research Associate, DMPK, Drug Discovery (Bioanalytical)
- Employer
- Maze Therapeutics
- Location
- South San Francisco, CA, United States
- Start date
- Nov 3, 2020
View more
- Discipline
- Science/R&D, Research
- Required Education
- Associate Degree
- Position Type
- Full time
- Hotbed
- Biotech Bay, NextGen Bio
Job Details
We are seeking a qualified bioanalytical Research Associate with experience using LC-MS for measurement of small molecule concentrations in various matrices (i.e. blood, plasma, tissues, etc.). The ideal candidate will be familiar with various sample extraction techniques and should be able to perform routine LC-MS method development, maintenance and troubleshooting. Experience with high resolution mass spectrometers (Q-Exactive), Sciex QQQs and Phoenix WinNonlin software is a plus. You will collaborate with other drug discovery researchers on small molecule analysis and engage in a fast paced, scientifically driven company – having fun while on a mission to get results.
Your Role in Navigating the Maze:
- You will develop LC-MS methods for the analysis of small molecules
- Prepare and analyze PK samples; calculate PK parameters and write PK/TK reports
- You will perform routine LC-MS maintenance
- You will conduct in vitro studies to determine metabolic stability, plasma protein binding, etc.
- Coordinate with CROs for scheduling of studies and shipment of samples
- As a member of Drug Discovery, you will collaborate with drug discovery departments on analysis and new methods
Your Navigation Tools:
- Bachelor's or Master's in a life science discipline with 3+ years' experience in DMPK in the biotech/pharmaceutical industry
- A minimum of 1 year of experience with LC-MS operation, preferably in a fast-moving environment
- Demonstrated knowledge of PK parameters and general DMPK concepts is desired but not necessary
- A passion for bioanalysis and drug discovery and a willingness to learn more methods and techniques
- Results driven and attentive to detail, with an eagle eye for LC-MS analysis
- Excellent communication skills and ability to work in a team-based environment is essential
Company
Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations.
What are genetic modifiers?
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
The Maze approach
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.
- Website
- https://mazetx.com/
- Location
-
171 Oyster Point Blvd, Suite 200
South San Francisco
CA
94080
United States
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