Senior Research Associate, Protein Engineering

Who we are

Atreca is an integrated biotechnology company located in South San Francisco, California (moving in 2021 to a new campus in San Carlos, CA). We apply our proprietary drug discovery platform to profile clinically relevant, active B cell responses in patients receiving successful treatment and, in turn, develop a portfolio of antibody therapeutics against novel tumor targets with the potential to treat large patient populations. Atreca seeks talented, driven individuals who are dedicated to making a positive impact on human health and are motivated to become key members of a growing biotechnology company.

Position Summary:

We are seeking an enthusiastic and motivated Senior Research Associate to join our Protein Engineering group. The successful candidate will play a key role producing and characterizing antibodies and engineered bispecifics in support of pre-clinical studies. This position will have the opportunity to interact and collaborate with a multidisciplinary team and utilize a variety of biophysical techniques to characterize novel therapeutics.

Duties & Responsibilities:

• Scout small-scale productions and develop new purification methods to support scale ups of novel therapeutics (antibodies and bispecifics)
• Produce and purify novel therapeutics at multi-Liter scale for use in pre-clinical studies
• Develop and perform analytical methods, including SEC, IEX, HIC, MALS, BLI, SPR, Tm/Tagg and SLS/DLS
• Catalog and integrate materials and results into informatics systems
• Work with other project team members and communicate results with the team
• Follow laboratory safety guidelines and practices

Required Skills and Qualifications:

• MS in Cell Biology, Molecular Biology, Immunology, Bioengineering, etc., or BS/BA with 2+ years of relevant research experiences (industry experience preferred)
• Experience with mammalian recombinant protein production required 
• Experience with FPLC, HPLC, SDS-PAGE required
• Experience with HEK293 or CHO transient transfection preferred
• Experience with bispecific antibodies a plus
• Strong analytical skills, excellent communication skills, and attention to detail
• Track record of being adaptable, self-motivated, and scientifically rigorous
• Ability to work in a team, prioritize tasks, and drive projects to completion