Scientist I/II, Translational Sciences
Who we are
Atreca is an integrated biotechnology company located in South San Francisco, California (moving in 2021 to a new campus in San Carlos, CA). We apply our proprietary drug discovery platform to profile clinically relevant, active B cell responses in patients receiving successful treatment and, in turn, develop a portfolio of antibody therapeutics against novel tumor targets with the potential to treat large patient populations. Atreca seeks talented, driven individuals who are dedicated to making a positive impact on human health and are motivated to become key members of a growing biotechnology company.
The translational scientist will be involved in the transition of Atreca's antibody programs into clinic.
The successful candidate will apply her/his skills and expertise regarding tissue-based assays to contribute to Atreca’s antibody-target characterization research. In particular, the scientist will apply her/his knowledge of histology and tumor biology to discover and understand the biology and mechanism of action of Atreca therapeutic antibodies as well as understanding the changes in tumor microenvironment as a result of treatment. The position reports to the Associate Director of Translational Sciences. The candidate’s expertise with advanced immunohistochemistry/immunofluorescence, other histological methods including image analysis and oncology will help us to discover and characterize novel tumor antigens and develop anti-tumor drugs.
Duties and Responsibilities
- Utilize expertise in immunology, tumor biology or related field to analyze characteristics of novel patient-derived antibodies, including tumor-selective binding and localization, discern mechanism(s) of action and contribute to early stage biomarker development using histological assays
- Design/perform/oversee studies using histological techniques to assess tissue cross-reactivity
- Apply a variety of histological approaches including amplification and antigen retrieval techniques and multiplex IF
- Perform staining, tissue distribution, and subcellular analyses of immunoreactive tumor and normal tissues
- Generate, collect, and analyze experimental results using microscopy; proper experimental recording and data management
- Coordinate activities with functional and Project team members
- Report data to project teams and management
- Responsible for tissue processing and slide preparation
- Proper maintenance/tracking of collected samples and slides
- General lab duties such as preparation of reagents and stocking of supplies
- Follow laboratory safety guidelines and practices
Required Skills and Qualifications
- Absolutely Required: PhD, preferably in oncology, tumor biology, or related field.
- Absolutely Required: 0-4 years of post-graduation experience, title will commensurate with experience
- Absolutely Required: Expertise in tissue-based assays [tissue processing, histological slide preparation, immunohistochemistry/immunofluorescence, microscopy and image analysis].
- Absolutely Required: Ability to work among a highly collaborative and dynamic team, great at multi-tasking, flexible, and enjoy working and delivering in a fast-paced environment
- Absolutely Required: Excellent trouble shooting, organization, and planning skills
- Experience with digital pathology analysis systems, a plus
- Experience performing small scale primary antibody modification/labelling, such as biotinylation, a plus
- Excellent written and oral communication and presentation skills