Associate Scientist, Immuno-Oncology

Location
Cambridge, MA, United States
Posted
Nov 01, 2020
Ref
705503350
Hotbed
Genetown
Required Education
Masters Degree/MBA
Position Type
Full time
Our mission:

Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

An exciting opportunity for an immunologist is available in the IO group at Intellia Therapeutics; where we leverage top-notch CRISPR technology to fully unleash the power of cell-based therapy for Immuno-Oncology. An ideal candidate is an immunologist with a background in T cell biology or T cell engineering with a strong interest in genomic editing and/or a working knowledge of Adoptive Cell Therapy (ACT) for the treatment of cancer.

We are seeking a highly skilled and motivated Associate Scientist/Senior Associate Scientist for our Immuno-Oncology group. The primary responsibility for this position is developing and optimizing in vivo mouse models, in vitro and ex vivo assays to evaluate T cell function for cancer therapy.

Responsibilities
    • Advance the optimization of in vivo tumor mouse models for evaluation of engineered T cell modalities.
    • Generate edited T cells to test in in vivo and in vitro assays.
    • Implement and troubleshoot experiments, both independently and in collaboration with colleagues, to reach desired goals.
    • Communicate research and development findings with internal and external partners


Qualifications:
    • M.S. with 2-5 years industry experience or B.S. in immunology, cell biology or related field with 5-8 years' industry experience
    • Experience working with human or mouse T cells, including in vitro profiling by flow cytometry and functional assays T cell proliferation and cytotoxic killing assays, ADCC assay, cytokine profiling assays
    • Experienced with multicolor flow cytometry
    • Demonstrated understanding and experience with human and mouse tumor models
    • Experience with viral and non-viral delivery methods to T cells a plus
    • Excellent interpersonal skills and ability to work efficiently and productively in a highly dynamic, scientifically rigorous and fast-paced environment
    • Proficient in animal handling, including i.p. and/or s.c. injections
    • Basic molecular biology skills required, advanced skills highly desired
    • Expertise in animal imagining; tumor growth and/or T cell profiling is highly preferred
    • Working knowledge of immunology and oncology is highly preferred
    • Working knowledge of CRISPR/Cas9 gene editing and gene editing experience a plus


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What Intellia Stands For:

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.

- Explore because we seek new ways to tackle disease. Explore with unbounded minds...free from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.

- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Intellia's web-based application process is managed through Lever. Information submitted through application forms is collected by Lever and subject to Lever's privacy policy .