Computational Biologist

Cambridge, MA, United States
Oct 31, 2020
Science/R&D, Biology
Required Education
Bachelors Degree
Position Type
Full time
Our mission:

Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Intellia Therapeutics is seeking a computational biologist to support the development of CRISPR/Cas9 based therapeutics for immuno-oncology applications. The ideal candidate will play a critical role in building an informatics platform for the development of personalized cell therapies. A background in computational biology, immunology, cancer genomics, and/or quantitative methods is preferred. A desire to solve challenging problems on the way to creating next-gen cancer therapeutics is a must.

    • Define and develop analysis pipelines to analyze single cell sequencing, somatic mutations, TCRs, and predictive biomarkers.
    • Apply rigorous statistical methods to drive actionable insights from large scale datasets.
    • Collaborate with a diverse team of experimentalists, computational scientists, and clinicians to address key therapeutic questions in a data-centic manner.
    • Analyze internal and external datasets to determine the genomic and transcriptomic properties of effective T cell therapeutics.

    • BS/MS in Bioinformatics or related field with at least 5 years of industry experience or Ph.D. in Computational Biology/Bioinformatics or related field with 1+ years of industry experience
    • Ability to write clear and effective code in bash, R, Python, and/or C++.
    • Experience working with WES, WGS, RNAseq, TCR-sequencing, and/or single cell sequencing data.
    • Working knowledge of cancer genomics and immunology or the ability to learn quickly.
    • Strong grasp of methods and tools for statistical inference and machine learning.
    • Proven ability to work effectively with a cross-functional team.
    • Strong communication and time management skills.

Preferred Skills:
    • Experience with workflow management software include but not limited to snakemake, Cromwell, reflow, wdl, and others.
    • Experience with software development in a cloud environment (AWS) is a plus.
    • Ability to create containerized workflows with docker.
    • Familiarity with git and/or other version control systems


What Intellia Stands For:

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.

- Explore because we seek new ways to tackle disease. Explore with unbounded from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.

- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Intellia's web-based application process is managed through Lever. Information submitted through application forms is collected by Lever and subject to Lever's privacy policy .