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Senior Scientist Modeling & Simulation

Employer
Amgen
Location
Thousand Oaks, CA, US
Start date
Oct 31, 2020

View more

Discipline
Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Beach, Best Places to Work

Job Details

Amgen provides a collaborative and creative culture in a company with a consistent track record of innovation. Our culture encourages open dialogue and diverse views to land on the best solutions, and we help ensure our staff are equipped to excel today and tomorrow.

The Amgen Clinical Pharmacology Modeling and Simulation (CPMS) team is seeking a Senior Scientist who will be based at our Thousand Oaks, CA corporate offices. As part of the Clinical Pharmacology, Modeling and Simulation department, the Modeling and Simulation Senior Scientist will support Amgen clinical development and translational sciences programs across multiple therapeutic areas with emphasis on oncology.

Key responsibilities of the Senior Scientist include:
  • Building pharmacostatistical models to support Population Pharmacokinetics/Pharmacodynamic (PKPD) and exposure-response analyses using relevant state of the art modeling and simulation techniques.
  • Training in binary and categorical and binary data analyses, time-to-event (hazard) models/Survival analysis, Poisson models, MCMC and Bayesian methods as applied to exposure-response analyses and Population PK and PKPD analysis.
  • Performing meta-analysis using proprietary and/or literature data.
  • Participating in cross-functional project teams and providing scientific input for dose selection, early and late study designs using modeling and simulation inputs.
  • Supplying to clinical pharmacology strategy for the programs and implementing project plans.
  • Generating modeling reports and contribute to the summary documents for regulatory submissions.


Basic Qualifications

Doctorate degree and 2 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience

Or

Master's degree and 5 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience

Or

Bachelor's degree and 7 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience

Preferred Qualifications
  • PhD in pharmaceutical sciences/Pharmacometrics, applied statistics/mathematics, biostatistics, and/or engineering or related fields with equivalent professional degrees (e. g. MD, PharmD) with 3 years of PK/PD or statistical modeling experience
  • 3+ years industry or relevant academic experience in pharmacometric analyses and/or applied biostatistics of small molecules and/or biologics.
  • Proficiency in modeling software (e. g. NONMEM, SAS, R/S-Plus, WinBUGS, STAN, MATLAB)

We understand that to efficiently sustain and grow as a global enterprise and deliver for patients - we must ensure a diverse and inclusive work environment.

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like sophisticated human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and improves its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Company

We are all different, yet we have this in common: our mission to serve patients. This sense of shared purpose is key to our becoming one of the world’s leading biotechnology companies. It guides us as we continue to launch new medicines and reach millions of patients worldwide.

We live the mission.

We win together.

We thrive on continual challenge.

Our team of 22,000+ scientists and professionals worldwide bring distinct perspectives and experiences to all we do. We leverage our global talent to achieve together—to research, manufacture and deliver ever-better products and greater depth to our mission.

At Amgen, there is a strong correlation between our high level of diversity and performance. Because addressing issues with a wider range of perspectives and approaches leads to more creative problem-solving. Together, we’re transforming the promise of science and biotechnology into therapies that have the power to restore health.

Connect with us to explore how you can Win, Live, and Thrive at Amgen.

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Company info
Website
Phone
805-447-1000
Location
Corporate Headquarters
One Amgen Center Drive
Thousand Oaks
California
91320-1799
United States

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