Computational Biologist, Metagenomics

South San Francisco, South CA, South United States
Oct 30, 2020
Science/R&D, Biology
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time

Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14, and Casɸ, Mammoth Biosciences can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Mammoth is democratizing disease detection with easy and affordable point-of-care tests that allow real-time and simultaneous detection of multiple conditions, along with high-throughput tests that allow for unprecedented testing volume. Further, the company is transforming disease treatment with its proprietary micro-sized CRISPR proteins that enable new editing and delivery options. Based in San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX, and 8VC, and leading individual investors including Brook Byers, Tim Cook, Bob Nelsen, and Jeff Huber.


Mammoth is seeking a computational biologist with expertise in big data mining and metagenomics to join its growing Discovery team. The Discovery team is responsible for developing novel CRISPR-associated (Cas) nucleases for genome editing and diagnostic applications.

The successful candidate will be responsible for designing computational workflows to primarily identify Cas nucleases and related proteins for genome editing and diagnostic applications. In addition, the individual will be responsible for designing metagenomic assembly pipelines and occasionally helping to collect environmental data samples. The successful candidate will work collaboratively with a diverse group of scientists and engineers to build new tools to beat COVID-19 and cure genetic disease.

    • Develop tools to classify and characterize proteins of unknown function
    • Computationally investigate protein diversity
    • Analyze large-scale metagenomic databases
    • Genome assembly and annotation from environmental sequencing samples
    • Work with experimental team to leverage metagenomics to supplement experimental lab work

    • BS, MS or Ph.D. in molecular biology, biochemistry, computational biology, software engineering or a related field
    • Familiar with existing bioinformatics databases, tools, and best practices
    • Proficiency with scripting in Python and R
    • Proficiency working with Linux systems
    • Experience working with Docker and Conda
    • Ability to contribute to the development of multiple pipelines
    • Understanding of sequencing analysis methods (assembly, clustering, gene calling, functional annotation)

    • Experience collecting, sequencing, and processing metagenomics samples
    • Experience with RNA structure prediction
    • Experience with protein classification and structure prediction.
    • Experience with Pearl, Java, C++
    • 4 years of experience in metagenomics in academia or industry

    • Competitive salary with equity
    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Free breakfast/lunch/dinner/barista
    • Free gym
    • Public transportation commuter subsidy
    • 401(k) matching