AbbVie

Principal Scientist I/II, DMPK-BA Oncology & Virology Project Lead

Employer
AbbVie
Location
San Francisco, CA, United States
Posted
Oct 30, 2020
Ref
2007156
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Oncology and virology are key therapeutic area for AbbVie, with both a mature portfolio and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer and infectious disease. AbbVie is expanding its oncology and virology organization focusing on the discovery and development of novel therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots combine their expertise in immuno-oncology, cell therapies, apoptosis, cell-signaling, and virology with their knowledge of bispecific antibodies, antibody-drug conjugates, and covalent inhibitor technologies to discover and develop novel treatments.
The Drug Metabolism, Pharmacokinetics, and Bioanalysis (DMPK-BA) group is searching for a project representative in Lake County, IL or South San Francisco to provide biologics project support (incl. antibody-drug conjugates, immuno-oncology biologics, and bispecific antibodies) in oncology and virology discovery and development phases. The position requires close collaboration with Discovery project teams and other stakeholders, developing and executing DMPK-BA and PK/PD strategies necessary to facilitate the advancement of optimized candidate molecules.

Key Responsibilities:
  • Develop and drive the DMPK-BA and PK/PD strategy for large molecule oncology and virology discovery and preclinical projects to support decisions and milestone transitions
  • Serve as a DMPK-BA representative on project teams supporting the development of novel biologics; collaborate with project team members (e.g., clinical pharmacology, protein analytics, discovery, toxicology) and groups within DMPK to generate relevant data guiding target validation, biomarker selection, and candidate selection
  • Effectively communicate DMPK-BA and PK/PD strategy and knowledge to project teams, functional leaders, and other key stakeholders to ensure alignment and influence decisions
  • Demonstrate thorough understanding of the PK/PD and DMPK aspects necessary for the selection and characterization of antibodies, including bispecific antibodies and antibody-drug conjugates
  • Coordinate and request PK, PK/PD, and bioanalytical studies in a timely manner and communicate protocols, timelines, needs and results back to team, ensuring optimized cycle times
  • Conduct value-added PK/PD-related quantitative analyses to support project team or project strategy decision-making
  • Serve as a liaison with bioanalytical groups to ensure timely reagent generation, method development and sample analysis
  • Prepare DMPK-BA sections of regulatory documents (IB, IND, BLA); provide responses to regulatory questions and ensure generation of appropriate reports

Level and compensation will be commensurate with experience
Equal Opportunity Employer Minorities/Women/Veterans/Disabled


Qualifications

Qualifications:
  • Bachelor with extensive experience (14+ years), Masters with substantial experience (12+ years), or Doctorate (Ph.D.) with at least 6 years of experience in the oncology or virology pharmaceutical or biotechnology industries
  • Experience independently representing DMPK on biologics project teams is required (expertise with novel modalities is preferred)
  • Expertise with PK analysis of biologics and relevant data analysis software such as Phoenix/WinNonlin is required
  • Experience with advanced modeling software such as MATLAB/Simbiology, R, Python, or Berkeley Madonna is desired
  • Understanding of biologics PK/PD modeling and analytical assays for measuring biologic molecules and biomarkers (including ligand binding and mass spectrometry assays) in preclinical study samples is desired
  • Demonstrated scientific leadership including generating original scientific investigative strategies and guiding those efforts to an effective and productive outcome
  • Recognized expert in his/her discipline
  • Demonstrated publication or patent record; lead/senior author contributions a plus
  • Ability to influence, negotiate and communicate effectively with both internal and external stakeholders; ability to work well in a collaborative fast-paced team environment
  • Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as team player and project driver
  • High degree of flexibility in adapting to different projects and people; excellent networking and relationship-building (both internal and external) skills
  • Passion for data analysis, solving technical problems and applying new technologies to further scientific goals

Key Leadership Competencies:
  • Builds strong relationships with peers and cross-functionally with partners outside of team to enable higher performance
  • Learns fast, grasps the "essence" and can change course quickly where indicated
  • Raises the bar and is never satisfied with the status quo
  • Creates a learning environment, open to suggestions and experimentation for improvement
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality

Significant Work Activities
N/A
Travel
Yes, 5 % of the Time
Job Type
Experienced
Schedule
Full-time
Job Level Code
M
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.