Senior Scientist II/ Principal Research Scientist I, Computational Immunology

Cambridge, MA, United States
Oct 30, 2020
Required Education
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

The Genomics Research Center (GRC) is a center of excellence for genetics and genomics that supports both Discovery and Development. The GRC plays an integral role towards our goal of developing world class genetics and genomics research, focusing on finding the right targets and helping us better understand not only human disease biology but also the behavior of and response to our drugs in clinical trials. Within the GRC, the Department of Bioinformatics is responsible for data analysis and provides analytical insight for both internal and external data. This involves the identification and characterization of underlying genetic, epigenetic, or genomic factors that are associated with disease diagnosis, prognosis and response (efficacy and safety) to drug treatment, identification of new targets, and interpretation of the impact of genetic and genomic evidence from population-based studies. We have an exciting opportunity for a Principal Computational Immunologist, based in Cambridge Massachusetts. The candidate will work closely with computational biologists and research project teams in Immunology and virology discovery and Harvard Medical school to support analyze genetics and single cell and multi-omics datasets to derive insights into immunological and infectious diseases, such as SARS-COV-2, identify novel therapeutic targets and biomarkers specific to patient cohorts and Abbvie pipeline drugs.

Key Responsibilities:
  • Collaborate with research & clinical scientists to conceive informatics analysis strategy and independently execute bioinformatics analysis, particularly focusing on functional interpretation and hypothesis generation that support discovery and pre-clinical studies such as new target identification and biomarker development
  • Collaborate with bioinformatics scientists and data engineers for complex and integrated bioinformatics analyses.
  • Identify relevant internal and external data and knowledge resources and propose integration mechanisms for immunology data integration
  • Be abreast with most current systems analysis methodology and algorithms and introduce them in-house when appropriate.
  • Communicate analytical analysis verbally and in writing for scientific and technical audiences.



Position will be hired based on level of experience.
  • PhD in Biological sciences (immunology strongly preferred) with strong quantitative background, involving the analysis of large scale complex data such as next generation sequencing, microarray etc. with 10+ years of experience.
  • Hands on experience in genomics (single cell preferred), immunoprofiling (CyTOF, immune cell repertoire) data analyses using existing and custom pipelines are required.
  • Experience in research project management is required.
  • Knowledge in functional analysis tools (IPA, MetaCore, GSEA, DAVID, etc.) and relevant databases (GEO, GTEX, DICE, etc.) and experience in developing custom computational analysis pipeline leveraging these resources is highly preferred
  • Fluent in scientific scripting languages such as R, Perl/Python.
  • Very comfortable working in both linux and windows environment.

Key AbbVie Competencies:
  • Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance.
  • Learns fast, grasps the "essence" and can change the course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Significant Work Activities
Job Type
Job Level Code
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.