Scientist I, Pharmacology

Location
Brisbane, California, United States
Posted
Oct 27, 2020
Ref
901616636
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time
MyoKardia is seeking a strong Cardiovascular Pharmacologist with a track record of evaluating the therapeutic effects of small molecules in ex vivo or animal models of cardiovascular disease. The successful candidate will provide independent guidance as well as hands-on expertise in the study design, execution, and reporting of in vivo and/or ex vivo studies. This position will also involve serving as pharmacology representative on interdisciplinary, cross-functional drug discovery and development project teams.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

Develop, design, and execute scientific strategies to gain an understanding of primary and secondary pharmacology mechanisms, biomarkers, translational potential, and safety for discovery stage programs
    • Implement and use relevant ex vivo models to study cardiovascular physiology and pharmacology, with a primary focus on muscle fiber mechanics
    • Design, execute, and report/summarize studies with novel small molecules that demonstrate detailed proof of mechanism
  • Execute/Report studies to support project advancement
  • Serve as a project team representative for pharmacology as needed
  • Lead cross-functional teams and/or initiatives
  • Scientifically mentor junior staff
  • Contribute and serve as primary author for pre-clinical and clinical reports/documents
  • Write protocols for IACUC approval and work with IACUC committees

EDUCATION/EXPERIENCE/SKILLS:

Education:
  • Requires an advanced degree, such as DVM, MD, and/or PhD with demonstrable expertise in physiology, pharmacology, biochemistry, or related discipline.

Experience:
  • 1-2+ years related experience in a cardiovascular laboratory setting; may include post-doctoral experience.
  • Hands-on working and directing knowledge of scientific principles and concepts, as well as of both established and state-of-the-art ex vivo and in vivo cardiovascular assessment tools.
  • Demonstrable scientist performance and track record in the field with peer-reviewed publications and accomplishments.
  • Excellent verbal and written communication skills, with a demonstrated ability to work independently and effectively in a team and cross-functional setting.
  • Effective and demonstrable leadership skills.