Scientist I, Pharmacology

Brisbane, California, United States
Oct 27, 2020
Biotech Bay
Required Education
Position Type
Full time
MyoKardia is seeking a strong Cardiovascular Pharmacologist with a track record of evaluating the therapeutic effects of small molecules in ex vivo or animal models of cardiovascular disease. The successful candidate will provide independent guidance as well as hands-on expertise in the study design, execution, and reporting of in vivo and/or ex vivo studies. This position will also involve serving as pharmacology representative on interdisciplinary, cross-functional drug discovery and development project teams.


Develop, design, and execute scientific strategies to gain an understanding of primary and secondary pharmacology mechanisms, biomarkers, translational potential, and safety for discovery stage programs
    • Implement and use relevant ex vivo models to study cardiovascular physiology and pharmacology, with a primary focus on muscle fiber mechanics
    • Design, execute, and report/summarize studies with novel small molecules that demonstrate detailed proof of mechanism
  • Execute/Report studies to support project advancement
  • Serve as a project team representative for pharmacology as needed
  • Lead cross-functional teams and/or initiatives
  • Scientifically mentor junior staff
  • Contribute and serve as primary author for pre-clinical and clinical reports/documents
  • Write protocols for IACUC approval and work with IACUC committees


  • Requires an advanced degree, such as DVM, MD, and/or PhD with demonstrable expertise in physiology, pharmacology, biochemistry, or related discipline.

  • 1-2+ years related experience in a cardiovascular laboratory setting; may include post-doctoral experience.
  • Hands-on working and directing knowledge of scientific principles and concepts, as well as of both established and state-of-the-art ex vivo and in vivo cardiovascular assessment tools.
  • Demonstrable scientist performance and track record in the field with peer-reviewed publications and accomplishments.
  • Excellent verbal and written communication skills, with a demonstrated ability to work independently and effectively in a team and cross-functional setting.
  • Effective and demonstrable leadership skills.