Lead Computational Scientist

Cambridge, MA, US
Oct 27, 2020
Required Education
Position Type
Full time

Black Diamond Therapeutics is a precision oncology medicine company pioneering the discovery and development of small molecule, tumor-agnostic therapies. Black Diamond targets undrugged mutations in patients with genetically defined cancers for whom limited treatment options currently exist. Black Diamond is built upon a deep understanding of cancer genetics, protein structure and function, and medicinal chemistry. The Company's proprietary technology platform, Mutation-Allostery-Pharmacology, or MAP, platform, is designed to allow Black Diamond to analyze population-level genetic sequencing data to identify oncogenic mutations that promote cancer across tumor types, group these mutations into families and develop a single small molecule therapy in a tumor-agnostic manner that targets a specific family of mutations.

We have an immediate opening for an experienced and highly motivated Lead Computational Scientist to help us build and improve our proprietary AI platform for precision oncology. You will work closely with bioinformaticians and structural proteomics scientists to develop and improve predictive models.

  • Implement and apply structural prediction methods to enhance the power of our machine learning platform
  • Lead scientific collaborations and method development efforts
  • Interact closely with project teams in wider research organization
  • Be a thought leader, stay informed of developments in the field and proactively identify novel scientific approaches


  • PhD in computational biophysics/chemistry, with at least 5-10+ years of relevant work experience in biomolecular simulations.
  • Expertise in Molecular Dynamics simulations, with a solid knowledge of theory and applications of MD, is required
  • Experience in cloud computing (AWS preferred) is a plus
  • Programming skills are a plus
  • Strong peer-reviewed publication record
  • Ability to independently solve problems, to think critically and creatively as part of a fast-paced research team.
  • Strong communication skills and the ability to communicate results to the research organization

Work Location:

The role will be based out of the Cambridge office, and preference will be given to candidates who live in Massachusetts.

Work Environment:

This job operates in a professional office environment. This role routinely uses standard office equipment.

Physical Demands:

The physical demands described here are representative of those that must be met by an employee to successfully perform he essential functions of this job. While performing the duties of this job, the employee is occasionally required to stand; walk; sit; used hands to fingers, handle, or feel objects, tools, or controls; reach with hands and arms; climb be stairs; talk or hear. The employee must occasionally lift or move office products and supplies, up to 20 lbs.

Black Diamond Therapeutics is an equal opportunity employer and welcomes and encourages all applications. Diversity and inclusion are important core values and will encourage our creativity and growth as a company. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.