Senior Scientist I/II

Lake County, IL, United States
Oct 26, 2020
Required Education
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Drug Discovery addresses key unmet medical needs through the identification and validation of therapeutic targets, generation of leads, and optimization of those leads into drug candidates for clinical evaluation. As a member of the High Throughput Screening and Molecular Characterization group in the Drug Discovery Science and Technology (DDST) area, the Senior Scientist will be responsible for designing and developing screening strategies, and delivering high quality screening data from validated screens to drive lead series identification. In addition, he/she should be implementing and executing primary biochemical and/or cellular assays that support small molecule lead generation and optimization efforts for medicinal chemistry at our Chicago area research site. The individual should have a broad knowledgebase and demonstrated expertise in molecular biology/cell biology/immunology/immune-oncology/virology across various target classes and will work with multiple disease biology groups to develop, optimize and execute novel assays in various disease models that can be utilized in a high-throughput screening format. The successful candidate will collaborate in a cross-functional team, across several groups in the R&D organization.
Key Responsibilities:
  • The candidate will be responsible for in-vitro cell-based assay development, optimization and execution of primary and secondary screening for multiple therapeutic areas including immunology, immune-oncology and antiviral therapeutics. He/she should also be flexible to explore and learn new assays and technologies depending on project needs.
  • He/she should be capable of engaging and collaborating with disease area teams and make substantial contributions to the conception and execution of screens including mechanism of action studies within strict time and quality tolerances.
  • Supervise team members, as needed, to conduct experiments, analyze and interpret datasets. Present results relevant to target activity, engagement, validation, mechanistic studies, structure-activity relationship etc. in team meetings.
  • Collaborate actively within the group and cross functional team to execute projects and coordinate discovery efforts.
  • Publish/present project-related research in high-impact peer-reviewed journals and scientific meetings.


Position will be hired based on level of education and experience.
  • PhD or Master's degree with 5+ years' experience in immunology/immune-oncology/ molecular biology. Additional virology experience is preferred.
  • Demonstrated experience in research conducting biochemical, cell, and molecular biology experiments. Experience in flow cytometry is required.
  • Expertise in mammalian cell culture is required. Experience in virus replicon, cytopathic, plaque assays and ELISA would be desirable.
  • Experience in working as part of a multi-disciplinary team focused on the discovery and advancement of novel therapeutic mechanisms as well as having a sustained track record of delivering high quality datasets.
  • Familiarity with assay technologies, automation, and high throughput screening approaches.
  • Demonstrated ability to train and supervise other scientists
  • Effective written/oral communication skills and a proven track record of problem-solving and publication.
  • Collaborative experience with external partners is a plus.

Significant Work Activities
Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Yes, 5 % of the Time
Job Type
Job Level Code
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.