Senior Research Associate - In Vitro Pharmacology

Location
Cambridge
Posted
Oct 25, 2020
Ref
4828171002
Hotbed
Genetown
Required Education
Masters Degree/MBA
Position Type
Full time
JOB PURPOSE

Sana Biotechnology is looking to expand our team with hard-working individuals who believe in the potential of cells as engineered medicines, have the vision to do creative things, and the determination to execute upon that vision. As a member of the In Vitro Pharmacology and Biomarker Discovery group, you will work within a highly dynamic and cross-functional environment on projects of diverse scope and across multiple therapeutic areas. To accelerate the development of transformative medicines, we seek a Senior Research Associate to build essential platform capabilities as well as develop and implement functional assays to support biomarker discovery, IND enabling studies, platform and research programs. The Senior Research Associate will perform in vitro characterizations of lead gene and cell therapy candidates in complex pharmacological and clinically relevant models. He/She will have experience culturing a diverse array of primary cell types and experience establishing and phenotypically characterizing in vitro models of disease. The successful candidate will have demonstrated technical proficiency, exhibit scientific rigor and independent thought as well as the ability to thrive in a team-oriented environment.

DUTIES AND RESPONSIBILITIES

Uses professional concepts in accordance with company objectives to solve problems in creative and effective ways.
  • Culture and maintain multiple primary cell types including but not limited to hepatocytes, T-cells, PBMC's, splenocytes, cardiomyocytes, as well as endothelial and stromal cell types.
  • Establish and validate in vitro functional assays using a variety of platforms (high-content imaging, incucyte, flow cytometry, ELISA, MSD, Luminex, HTRF, qPCR)
  • Responsible for thoughtful planning, coordination and execution of experiments.
  • Makes detailed observations, interpret results and document experimental methods in a well-maintained laboratory notebook.
  • Proven ability to work independently.
  • Presents results at team meetings.
  • Facilitates discussion with other team members as necessary to ensure the completion of the team's projects.
  • Comply with standard laboratory practices and company policies

QUALIFICATIONS

Basic Qualifications
  • Master's degree or Bachelor's degree with 3-4+ years of laboratory experience in an academic or industry setting and proven proficiency performing independent research.
  • Extensive hands-on experience culturing mammalian cell lines (primary and immortalized) with demonstrated competence in sterile cell culture technique and standard laboratory procedures.
  • Experience developing and characterizing in vitro models of disease.
  • Experience in the development of cell-based assays using a variety of platforms (Incucyte, High-content imaging, TR-FRET, ELISA, MSD, Flow Cytometry, Luminex, qPCR).
  • Ability to proactively engage groups with diverse functions within a highly matrixed organization.
  • Excellent oral and written communication skills, attention to detail and data quality, and experience working on cross-functional teams.
  • Technical proficiency, scientific creativity, independent thought and ability to actively communicate with scientists throughout the organization.

Preferred Qualifications
  • Industry experience
  • Experience with primary cell culture is highly preferred.
  • Research experience in liver biology and/or immunology.
  • Experience characterizing metabolic pathways and disease modeling