Associate Director, Translational Medicine
The Associate Director (AD), Translational Medicine supports key activities associated with translational biology and development of AnaptysBio's proprietary inflammation and immuno-oncology antibody programs towards the clinic. The candidate will work with a dynamic team to define, validate and develop relevant biomarkers that predict and monitor in vivo drug biological activity and efficacy in disease indications of interest to AnaptysBio's therapeutic focus. He/she will contribute to the preparation of documentation required for regulatory submissions, including INDs, and participate in the design and execution of clinical studies leading to proof of concept.
The Translational Medicine Department works together with other departments to actively contribute to the identification and selection of new targets to sustain the company's antibody discovery pipeline. There will be ample opportunities for the AD Translational Medicine to identify new target biology relevant to unmet medical needs associated with inflammation and immuno-oncology.
- Designs and executes translational biology studies supporting preclinical and clinical development of AnaptysBio's inflammation and immuno-oncology programs.
- Develops guidelines for selection, validation, and prioritization of translational biomarkers, ensuring alignment with AnaptysBio's product development strategies.
- Works closely with external research collaborators and contractors for preclinical and clinical translational efforts.
- Explores biomarker identification/validation and interface with the discovery and development teams throughout the development process.
- Represents development projects at management meetings as well to external stakeholders.
- Works with Project Management to develop timelines and budgets, and ensure that tasks are completed appropriately - establishing and monitoring measurable research milestones.
- Participates in new target identification, including translational biology assessment of emerging biology within therapeutic areas of strategic interest to AnaptysBio. Establishes and maintains a network of external experts for molecular and biological target identification and validation.
- Fully participates in the planning and preparation of documentation sections required for regulatory filings (e.g. INDs).
- Hire, lead, and develop Translational Medicine staff.
Knowledge and Competencies:
- Ability to effectively design, execute, and troubleshoot experimental protocols to develop new methodologies.
- Current working scientific knowledge of cellular and molecular immunology with a basic understanding of antibodies
- Extensive knowledge of mammalian cell culture, including standard cell biology techniques and, working knowledge of cellular signaling and ELISA assays
- Current knowledge of the design and implementation of multi-color flow cytometry-based screening experiments
- Familiarity with preclinical models of inflammation and autoimmune disease
- Familiarity with database searches
- Experience in developing fit-for purpose biomarker/bioanalytical assays
- Experience in development of quantitative analytical bioassays from complex matrices
- Ability to identify and implement (where and when appropriate) new technologies for the advancement of quantitative biomarker analytics
- Must be able to manage assay development and analysis queues and timelines
- Knowledge of drug discovery process and pharmacology is highly desirable
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
While performing the duties of this job, the employee is regularly required to:
- Sit and talk or hear.
- Frequently is required to use hands to finger, handle, or feel.
- Occasionally required to stand, walk, and reach with hands and arms.
- Must occasionally lift and/or move up to 10 pounds.
- Specific vision abilities required by this job include close vision and ability to adjust focus in order to read.
The work environment characteristics are representative of those an employee encounters while performing the essential functions of this job, typically in an open office environment. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
- The noise level in the work environment is usually moderate.
- May be required to travel by plane or car.
- This position requires working with biological and/or chemical hazards.
All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status.
Education & Experience
- Ph.D. in the Biological Sciences, with extensive experience in Life Sciences - at least 10 years of relevant, direct experience in preclinical clinical development up to Phase 2 clinical studies; or MD with 3-5 years' experience in early clinical development with proven ‘translational' expertise (clinician scientist PhD preferred).
- Proven scientific background with preference in the area of inflammation and immunology.
- Proven track record in the translational development of drug candidates to include drug treatment approaches, agents in development and the business landscape.