Senior Scientist, Protein Engineering

Who we are

Atreca is an integrated biotechnology company located in South San Francisco, California (moving in 2021 to a new campus in San Carlos, CA). We apply our proprietary drug discovery platform to profile clinically relevant, active B cell responses in patients receiving successful treatment and, in turn, develop a portfolio of antibody therapeutics against novel tumor targets with the potential to treat large patient populations. Atreca seeks talented, driven individuals who are dedicated to making a positive impact on human health and are motivated to become key members of a growing biotechnology company.

Position Summary

We are seeking an outstanding and highly motivated scientist to join our Protein Engineering group and become a key member of the research team. The successful candidate will exhibit a “drug hunter” mentality, rooted in protein engineering approaches. The candidate will lead cross-functional drug discovery projects that combine anti-tumor antibodies from our patient-derived portfolio with bispecific antibody engineering platforms, for example, T cell engagers, NK cell engagers, myeloid cell modulation, and cytokine fusions.

Duties and Responsibilities

• Lead bispecific projects from concept through design, engineering, and validation
• Collaborate with in vitro and in vivo pharmacology teams to integrate mechanism of action, protein engineering, and functional screening
• Expand in-house technologies as needed, for example, building and purifying various asymmetric bispecifics
• Enable faster and higher-throughput cycles of design/build/test/learn
• Contribute to patents, publications, and technical reports
• Follow laboratory safety guidelines and practices

Required Skills and Qualifications

• A degree in bioengineering, biochemistry, immunology, or related discipline
• PhD + 4, MS + 8, or BS + 10 years of relevant biotech/pharma industry experience
• Significant experience with engineering bispecific antibodies is preferred
• Significant experience with cancer immunotherapy is preferred
• Experience with FPLC and HPLC is a plus
• Experience with Biacore or Octet is a plus
• Experience with developability analyses and assays is a plus
• Experience with yeast display is a plus
• Experience with protein modeling and structure-based design is a plus
• Strong analytical skills, excellent communication skills, and attention to detail
• Track record of being innovative, adaptable, and scientifically rigorous
• Ability to work in a team, prioritize tasks, and drive projects to completion