Senior Scientist, Protein Engineering

94080, South San Francisco
Exact title commensurate with experience. Atreca is an equal opportunity employer.
Oct 22, 2020
Required Education
Position Type
Full time

Who we are

Atreca is an integrated biotechnology company located in South San Francisco, California (moving in 2021 to a new campus in San Carlos, CA). We apply our proprietary drug discovery platform to profile clinically relevant, active B cell responses in patients receiving successful treatment and, in turn, develop a portfolio of antibody therapeutics against novel tumor targets with the potential to treat large patient populations. Atreca seeks talented, driven individuals who are dedicated to making a positive impact on human health and are motivated to become key members of a growing biotechnology company.

Position Summary

We are seeking an outstanding and highly motivated scientist to join our Protein Engineering group and become a key member of the research team. The successful candidate will exhibit a “drug hunter” mentality, rooted in protein engineering approaches. The candidate will lead cross-functional drug discovery projects that combine anti-tumor antibodies from our patient-derived portfolio with bispecific antibody engineering platforms, for example, T cell engagers, NK cell engagers, myeloid cell modulation, and cytokine fusions.

Duties and Responsibilities

  • Lead bispecific projects from concept through design, engineering, and validation
  • Collaborate with in vitro and in vivo pharmacology teams to integrate mechanism of action, protein engineering, and functional screening
  • Expand in-house technologies as needed, for example, building and purifying various asymmetric bispecifics
  • Enable faster and higher-throughput cycles of design/build/test/learn
  • Contribute to patents, publications, and technical reports
  • Follow laboratory safety guidelines and practices

Required Skills and Qualifications

  • A degree in bioengineering, biochemistry, immunology, or related discipline
  • PhD + 4, MS + 8, or BS + 10 years of relevant biotech/pharma industry experience
  • Significant experience with engineering bispecific antibodies is preferred
  • Significant experience with cancer immunotherapy is preferred
  • Experience with FPLC and HPLC is a plus
  • Experience with Biacore or Octet is a plus
  • Experience with developability analyses and assays is a plus
  • Experience with yeast display is a plus
  • Experience with protein modeling and structure-based design is a plus
  • Strong analytical skills, excellent communication skills, and attention to detail
  • Track record of being innovative, adaptable, and scientifically rigorous
  • Ability to work in a team, prioritize tasks, and drive projects to completion