Research Associate / Senior Research Associate, Medicinal Chemistry
- Employer
- Maze Therapeutics
- Location
- South San Francisco, CA, United States
- Start date
- Oct 21, 2020
View more
- Discipline
- Science/R&D, Chemistry, Research
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Biotech Bay, NextGen Bio
Job Details
We are seeking a talented and highly motivated individual with a strong background in organic, synthetic or medicinal chemistry to join our dynamic and highly-collaborative drug discovery team. The successful candidate will be responsible for the synthesis, purification, and characterization of novel, biologically-active small molecules. This is a hands-on role utilizing cutting-edge techniques and advanced technology to contribute to novel molecules for therapeutic use.
Your Role in Navigating The Maze:
- Conduct multistep syntheses of complex small molecules supported with detailed characterization of intermediates and final products
- Design and execute experiments and tasks in consultation with chemistry colleagues.
- Propose new compounds for synthesis based on synthetic knowledge and SAR
- Evaluate and clearly report experimental results to supervisors and colleagues on a routine basis with special attention to data quality and reproducibility
- Summarize / interpret results and present findings in research meetings
- Integrate and utilize modern medicinal chemistry principles and tools.
- Learn new laboratory techniques, troubleshoot experiments, and ensure experiments are performed to a high standard
- Utilize scientific literature and databases such as SciFinder to design and implement efficient synthetic routes
- Collaborate with scientists across functions to develop and optimize newly generated molecules
Your Navigation Tools:
- BS/MS in Chemistry with at least 2 years of relevant laboratory experience in synthetic organic/medicinal chemistry
- Industry experience is highly preferred; experience working across teams on projects is preferred
- Demonstrated experience in multi-step organic synthesis, chromatographic purification methods, and compound characterization using modern analytical techniques (NMR, LCMS, HPLC, etc.)
- Interest in medicinal chemistry concepts with an ability to learn and adapt in a fast-moving environment
- Organized and detail-oriented record-keeping skills, ability to multi-task, and excellent verbal and written communication skills
- Demonstrated ability to independently in conceptualize and execute chemistry experiments
Company
Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations.
What are genetic modifiers?
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
The Maze approach
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.
- Website
- https://mazetx.com/
- Location
-
171 Oyster Point Blvd, Suite 200
South San Francisco
CA
94080
United States
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