Scientist/Sr. Scientist, DNA Encoded Chemistry, Library Discovery

San Francisco
Oct 20, 2020
Biotech Bay
Required Education
Position Type
Full time
Nurix is a science-focused company that is committed to bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating E3 ubiquitin ligases within the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation – a function vital to the healthy life of a cell – offering therapeutic opportunities in multiple disease areas. Nurix's scientific team has established an innovative drug discovery platform to identify selective inhibitors or activators of the UPS, enabling the development of novel therapeutics that can restore normal cellular homeostasis. In particular, Nurix has positioned itself as a leader in the burgeoning field of UPS degraders. Nurix was founded by internationally recognized experts in the UPS field before entering into multi-year strategic collaborations with multiple pharma partners to discover and develop next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix became a publicly traded company in July of 2020 and is based in San Francisco's biotechnology hub, Mission Bay – where academia and industry come together for cutting-edge life-saving research.


We are seeking a talented and highly motivated scientist with expertise in the synthesis of DNA encoded libraries and a strong background in synthetic organic chemistry and to join our Library Discovery team. You will join a group with two objectives:
1) Design and synthesize DNA encoded libraries and
2) Utilize these libraries to identify novel chemical matter with the potential to modulate the activity of UPS targets. You will first and foremost have previous experience in conducting DNA encoded library synthesis.

You may have also had experience conducting parallel reaction chemistry, split/pool methods, aqueous chemistry and linker chemistry related to the synthesis of drug conjugates. You will be interested in strategies to most efficiently navigate drug-like chemical space and will lead discovery programs that will use Nurix's DNA encoded libraries as the principal means of molecular search. As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

  • Ph.D. and/or postdoctoral studies that required synthesis of DNA encoded libraries with 0-5 years industry experience or B.S. with 2-7 years industrial DNA encoded libraries synthesis experience (years of relevant experience will impact level of hire)
  • Expert in synthetic organic chemistry methods and analytical tools, in particular LCMS
  • High level of creativity and productivity with strong synthesis problem-solving skills.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations, as organization publication policy has permitted
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department
  • Experience with chemistry involving biological macromolecules, i.e. antibodies and oligonucleotides, linker technologies, or the design and synthesis of chemical biology probes a plus
  • Familiarity with working with large data sets and the tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making.

Fit with Nurix Culture and Values
  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view