Senior Scientist, Functional Genetic Screening

Cambridge, MA, United States
Oct 16, 2020
Required Education
Position Type
Full time
Our mission:

Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Intellia is seeking a highly skilled Scientist/Sr Scientist, Functional Genetic Screening to join our Platform Biology team. The ideal applicant will be experienced with all aspects of functional genetic screening from library construction to sample preparation for NGS and data analysis. The successful candidate will develop and execute the basic screening platforms in primary human T cells and work with other teams to drive various screening projects. Hands-on experience with primary T cells is strongly desired.

    • Develop CRISPR-based screening platforms in primary human T cells
    • Drive both independent and cross-functional CRISPR screens in primary T cells
    • Analyze and interpret screen data with bioinformatics team for hit identification
    • Troubleshoot experimental problems

    • PhD in Cell Biology, Immunology, Molecular Biology or a related area with at least 0-5 years of industry experience
    • Demonstrated ability to clearly communicate scientific results in internal and external presentations and publications
    • Demonstrated ability to work independently and collaboratively in a dynamic, fast paced team environment
    • Experience managing a laboratory technicians or research associates is a plus
    • Experience performing CRISPR-based functional genetic screens
    • Experience with flow cytometry/FACS and/or magnetic bead-based cell separations
    • Hands-on proficiency with sample prep for NGS and knowledge of downstream data analysis
    • Ability to perform multiple work streams simultaneously
    • Experience isolating, culturing, and modifying primary human T cells


What Intellia Stands For:

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.

- Explore because we seek new ways to tackle disease. Explore with unbounded from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.

- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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