Scientist, Disease Biology

Cambridge, MA, United States
Oct 16, 2020
Required Education
Masters Degree/MBA
Position Type
Full time
Our mission:

Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Our Disease biology team is looking for a Scientist to lead projects related to the application of CRISPR/Cas9 for genetic disease. The Scientist will be responsible for developing, optimizing, and executing in vitro assays in support of our drug discovery activities, in both hepatic and extrahepatic settings. The ideal candidate will be experienced in developing cell-based and biochemical assays for mechanistic characterization of therapeutic targets and drug candidates. The candidate must exhibit strong interpersonal communication and organizational skills, eagerness to learn about new disease areas and techniques, and motivation to lead a cross-functional team in delivering reliable scientific data in a timely manner. The successful candidate will be able to leverage her/his existing experience with cell and tissue culture, gene expression analysis (e.g., qPCR, ddPCR), Western blotting, ELISA, and bioassay development. Creativity and intellectual curiosity are essential to the role, as is the ability to generate new therapeutic ideas and to distill complicated concepts into easy-to-understand and testable hypotheses.

    • Lead cross-functional, disease-focused project teams from initiation to DC stage
    • Communicate effectively within functional team and across a matrixed organization
    • Develop in vitro assays to interrogate biological processes and test novel therapeutics
    • Perform cell culture with rodent, primate, and human primary cells and cell lines
    • Deliver high quality data to help advance drug discovery projects in the therapeutic portfolio
    • Analyze and interpret data, and troubleshoot experiments
    • Generate new therapeutic hypotheses leveraging CRISPR/Cas9 gene editing
    • Manage junior scientists on the team

    • MS degree in biology or a related discipline with 4+ years of relevant experience, or PhD degree with 2+ years of relevant experience
    • Ability to work and think independently and to contribute as a part of a highly matrixed team
    • Experience of leading a diverse project team to successfully achieve objectives
    • Cell culture, including with primary human cell types
    • qPCR/ddPCR, Western blotting, ELISA
    • Bioassay development, optimization and validation
    • Experience with CRISPR/Cas9 technology
    • Knowledge of inherited diseases of the liver, nervous system, bone marrow, and/or muscle
    • Prior experience supervising, mentoring and developing junior scientific staff


What Intellia Stands For:

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.

- Explore because we seek new ways to tackle disease. Explore with unbounded from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.

- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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