Scientist(Junior/Senior), in vivo Pharmacology

650 East Kendall Street, Cambridge, MA 02142
$80,000.00 - $110,000.00 per year
Oct 16, 2020
Required Education
Masters Degree/MBA
Position Type
Full time

About the Company

Pinetree Therapeutics, Inc. is a biotech startup developing bispecific antibodies for cancer therapy. Our mission is to deliver on the promise of therapeutic antibodies to treat drug resistant cancers and immune disorders and create the next generation of transformative medicines for patients. We are a group of highly motivated, dedicated professionals working collaboratively in a multi-facetted team with the ultimate goal to improve patient care. Pinetree Therapeutics is located in the heart of Cambridge biotech, Kendall Square. If you are looking to join a dynamic team serving this ever-important mission, then Pinetree is the place for you!

Pinetree is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Pinetree will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Join us for career training and development, an exceptional work environment, a sense of community, and allow us to reward you for your accomplishments. Pinetree Therapeutics offers highly competitive salaries and comprehensive benefits, including medical and dental insurance, paid time off, and 401(k) with a generous company match.

The Role

Pinetree Therapeutics has an opportunity for an ambitious, self-motivated and results-driven junior/senior in vivo pharmacologist with a background in oncology. You will work collaboratively with our team to advance the translational efforts of our bispecific antibody platform targeting genetically defined cancers. We are eager to provide you with the opportunity to plan and perform in vivo anti-tumor efficacy and PK/PD studies in support of multiple drug discovery programs. Studies will include evaluating and establishing efficacy, PK/PD relationships as well as combination therapy strategies and biomarker identification.

We look forward to having your extensive experience with animal models of human cancers, with hands on in vivo skills (IP, IV, SC, PO dosing), and blood & tissue collection. You will further perform ancillary in vitro and ex vivo assays to characterize effects of lead drug candidates that may include Western blot, FACS, ELISA or other assays as needed.

We want your time at Pinetree to be transformative. We pride ourselves on providing a clear career path with opportunities for leadership, personal growth and professional development. This position will provide an opportunity to perform cutting-edge biological research in the field of oncology and immuno-oncology, in collaboration with internal and external scientists and clinical investigators.


  • PhD in oncology, biology, pharmacology (or equivalent) 3-5 years of post-graduate research experience preferred.
  • MS with >5 years of experience in in vivo research required.
  • Hands on in vivo skills(IP, IV, SC, PO dosing).
  • Experience in blood & tissue collection.
  • Excellent verbal and written communication skills.
  • Strong analytical and problem-solving skills.
  • Ability to work independently as well as in collaboration with other scientists as needed.
  • Knowledge of immune cell biology, particularly T and DC cells in cancer/ autoimmune and infectious disease models a plus.
  • Experience in immune cell characterization (e.g. using flow cytometry) and functional assay development a plus.
  • Experience in large data analysis a plus.

Recruitment & Staffing Agencies: Pinetree does not accept unsolicited resumes from any source other than candidates. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Pinetree, and Pinetree will not owe any referral or other fees with respect thereto.