Sr. Scientist, Reagent Lyophilization
- Employer
- Mammoth Biosciences
- Location
- San Francisco, CA, United States
- Start date
- Oct 16, 2020
View more
- Discipline
- Science/R&D, Biotechnology
- Required Education
- Masters Degree/MBA
- Position Type
- Full time
- Hotbed
- Biotech Bay
Job Details
OPPORTUNITY
Mammoth is looking for a Sr. Scientist, Reagent Lyophilization. This position is critical to Mammoth's charter of using innovative CRISPR enzymes in diagnostic products. This role leads a team charged with developing the lyophilization cycles for Mammoth's innovative CRISPR based detection reagent, transferring these into reagent manufacturing and executing the stability studies for all of Mammoth's assay reagents.
KEY RESPONSIBILITIES
- Organize and lead a team of scientists with chemistry and/or molecular biology backgrounds to develop the lyophilization cycles for several different types of reagents and for many different molecular assay targets.
- Determine the protective excipients that adequately protect the reagents enzymes during lyophilization.
- Recruit and hire the team members that share the vision for this team as the experts for the Lyophilization and Stability of Mammoth's assay reagents.
- Lead the designing, execution and reporting of the Stability Studies for all Mammoth assay reagents.
- Lead the interactions with Mammoth's contract manufacturing organizations to implement commercial lyophilization at the needed scale for successful assay commercialization.
- Be the Mammoth expert in Analytical Chemistry techniques to analyze the key characteristics of the assay reagents in liquid or lyophilized form.
- Write plans, protocols and reports that are compliant with 21 CFR 820 and ISO 13485.
REQUIRED QUALIFICATIONS
- A minimum of 5 years industry experience designing Lyophilization cycles
- Knowledge and experiences using and applying Karl Fisher moisture analysis methods, freeze dry microscopy, and differential scanning calorimetry to measure and assess the efficacy and stability of lyophilized reagents
- Experiences using the scientific method for lyophilization cycle design using the analytical techniques listed above along with Pirani gauge and thermocouple measurements
- Experiences with writing, executing and reporting on reagent stability studies including accelerated stability methods
- Experience successfully leading a scientific product development team of 3 or more people
- MS or Ph.D. in Chemistry, or Analytical Chemistry or Chemical Engineering
PREFERRED QUALIFICATIONS
- A minimum of 5 years industry experience designing Lyophilization cycles for a pharamceutical or IVD application within a 21 CFR 820 quality management system
- Participation in the development of at least 3 different products and encompassing a majority of the product development phases of Concept and Feasibility, Design, Verification, Validation, Design Transfer, Product Launch, Product Support
BENEFITS
- Competitive salary with equity
- Company-paid health/vision/dental benefits
- Unlimited vacation and generous sick time
- Free breakfast/lunch/dinner/barista
- Free gym
- Public transportation commuter subsidy
- 401(k) matching
Company
Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.
- Website
- http://www.mammoth.bio/
- Phone
- (650) 294-8583
- Location
-
South San Francisco
CA
94080
United States
Get job alerts
Create a job alert and receive personalized job recommendations straight to your inbox.
Create alert