Sr. Research Associate, Bioanalytical DMPK

Oct 15, 2020
Required Education
Associate Degree
Position Type
Full time
This position performs bioanalytical method development and analysis for non-clinical pharmaceutical analyses using LC/MS and LC/MS/MS techniques. This position also provides other necessary bioanalytical and mass spectrometry support to the company in small and large therapeutic molecules.

Good things are happening at Omeros!

Come join our Bioanalytical - DMPK Team!

Who is Omeros?

Omeros is a commercial-stage biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, complement-mediated diseases, disorders of the central nervous system and immune-related diseases, including cancers. In addition to its commercial product OMIDRIA (phenylephrine and ketorolac intraocular solution) 1%/0.3%, Omeros has multiple phase 3 and phase 2 clinical-stage development programs focused on complement-mediated disorders and substance abuse. Omeros also has a diverse group of preclinical programs including GPR174, a novel target in immuno-oncology that modulates a new cancer immunity axis recently discovered by Omeros. Small-molecule inhibitors of GPR174 are part of Omeros' proprietary G protein-coupled receptor (GPCR) platform through which it controls 54 new GPCR drug targets and their corresponding compounds. The company also exclusively possesses a novel antibody-generating platform.

Essential Duties & Responsibilities:

  • Develops and utilizes methods for non-clinical analysis of potential drug candidates in in-vivo and in-vitro biological samples; samples are analyzed utilizing LC/MS and LC/MS/MS techniques
  • Quantifies drug and metabolite compounds through LC/MS/MS in biological matrices of small and large therapeutic molecules. Develops HPLC and MS/MS method for the assay
  • Completes MS/MS structural elucidation on unknown metabolites or related substances with little to no technical assistance from supervisor
  • Makes detailed observations, analyzes data, interprets and presents results, using fundamental pharmacokinetic and ADME principals. Makes recommendations of the rank order of compounds in lead optimization/candidate selection from animal PK data and/or in vitro analyses
  • Investigates, creates and develops new sample analysis/extraction preparation methodologies and technologies for project and product advancement
  • Maintains high level of professional expertise through familiarity with scientific literature, on-line seminars or workshop attendance
  • Contributes in the training (extraction techniques, HPLC/MS operation) and preparation of new-hire Research Associates
  • May participate in scientific conferences and contribute to scientific journals
  • Requires a Bachelor's degree and a minimum of 8 years related experience or Masters degree with equivalent experience; level will be dependent on skills and experience
  • Experience with mass spectrometry and HPLC/MS and MS/MS techniques with an analytical and method development background
  • Knowledge of pharmacokinetics and previous experience with preclinical ADME work is desirable
  • Strong knowledge of scientific principals and concepts
  • Knowledge of the principles and practices of computer applications including word processing, spreadsheet, database management, pharmacokinetic (WinNonlin) software, presentation software and Internet search engines
  • Must have the ability to build and maintain positive relationships with management, peers, and subordinates
  • Excellent written and verbal skills required
  • Must display strong analytical and problem-solving skills
  • Attention to detail required
  • Must be able to work in a flexible environment
  • Intermittent physical activity including bending, reaching, pushing, pulling, or lifting up to 40 lbs.
  • May encounter prolonged periods of sitting or standing
  • This position requires working around hazardous material
If you have the experience, skills and knowledge we are seeking, we'd love to hear from you!

Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to or contact Omeros, asking for Human Resources, at (206) 676-5000.