Senior Process Development Associate

Location
South San Francisco, California, United States
Posted
Oct 14, 2020
Ref
929794304
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Thank you for your interest in a career at Senti Biosciences. We are passionate about developing cell therapies with the ability to outsmart cancer and other complex diseases. We find purpose and meaning in knowing that our efforts will soon improve the lives of patients and their families. With science as our foundation and empathy as our key guiding principle, colleagues become friends, managers become mentors, and with time, cancer becomes history.

Senti Bio is seeking a Senior Associate to join our Process Development group for cell therapy programs. A successful applicant will have prior experience with process development and scale up of gene modified cell therapies and be comfortable in a fast moving and nimble culture. Applicants should be familiar with culturing expanded allogeneic and autologous cell products, familiar with pre-clinical process development and GMP tech transfer to a CDMO, and adept at analytical methods and assays.

Responsibilities
    • Contribute to process development for cell therapy development programs, including natural killer (NK cells), mesenchymal stromal cells (MSCs), CAR-T cells and other therapeutic cell modalities.
    • Perform transductions on primary human cells via viral vectors and other gene delivery methods.
    • Support process optimization efforts to increase process robustness, improve transduction efficiency, cell yield and purity.
    • Independently perform experiments on process conditions and raw material qualification.
    • Develop genetically modified cells under quality-controlled conditions suitable for transfer to a GMP facility.
    • Collaborate with research teams on relevant product characterization assays (Flow Cytometry, ELISA , Luminex based assays and PCR)
    • Help design and execute experiments with great attention to detail.
    • Maintain accurate lab records and notebooks.
    • Author protocols, reports and standard operating procedure documents.
    • Present results in team meetings and deliver presentation to both small and large groups.


Qualifications
    • Bachelor's or Master's degree in Cell & Molecular Biology or related life science field, with 5+ years of process development experience.
    • Prior experience drafting SOPs and working with Quality Systems.
    • Experience with mammalian tissue culture including both adherent and suspension cells.
    • Proficiency with flow cytometry strongly preferred.
    • Ability to design and execute experiments with minimal technical supervision.
    • Ability to multitask and meet deadlines in a fast-paced environment.
    • Highly organized and detailed oriented with strong troubleshooting and problem solving skills.
    • Must be a team player, proactive and willing to work in a small team environment.
    • Must have excellent verbal and written communication skills.
    • Proficient with MS office and other commonly used software and technology platforms.
    • Self-motivated and eager to take on temporary responsibilities outside of initial job description.


Salary and Benefits
    • Competitive compensation package and title commensurate with qualifications and experience in the South San Francisco Biotech market.
    • Significant growth opportunity as the company expands


Senti Bio is the next generation therapeutics company that designs gene circuits and programs cells for tremendous therapeutic value. Our mission is to engineer an entirely new class of medicine that will transform people's lives by curing the most challenging diseases. We are proud to count NEA, 8VC, Amgen Ventures, Pear Ventures, Lux Capital, Menlo Ventures, Allen & Company, Nest.Bio , Omega Funds, Goodman Capital, and LifeForce Capital among their investors. Senti Bio is based in South San Francisco, CA, USA.