Scientist, VI Next (CRISPR)

Location
Tarrytown, NY, United States
Posted
Oct 13, 2020
Ref
20957BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
VelocImmune (VI) Next is a technology development group at Regeneron that investigates new modes of antibody, immune, and cell-based therapies. We are seeking a highly skilled and motivated scientist to join the team to support our cell/gene therapy efforts across Regeneron. The responsibilities of this position will include reagent screening, condition optimization, as well as technology development in the areas of nucleic acid therapeutics and gene editing.

As the Scientist, VI Next, a typical day might include the following:

- Optimizing CRISPR-based ex vivo gene editing platform, improving editing efficiency and minimizing off-target effects.

- Establishing and culture mammalian cell lines and primary cells.

- Establishing and optimizing CRISPR delivery methods; customizing CRISPR-based ex vivo gene editing protocols to different primary cell types.

- Designing and establishing assays, including functional assays, to evaluate gene editing efficiency and off-target effects; validating CRISPR-based gene editing at genetic, protein expression, and functional levels.

- Performing high throughput gRNA screening based on targeting efficiency and off-target effects.

- Innovating modifications in guide RNA design and chemistry to improve editing

- Conducting experiments using state-of-the-art molecular and cell biology techniques

- Designing experiments, analyzing data and communicating findings in meetings

THIS ROLE MIGHT BE FOR YOU IF:

- You have the ability to innovate and think out of the box

- You have excellent interpersonal skills

- You have the ability to work effectively with diverse groups - both large and small

- You have a high attention to detail

To be considered for this opportunity, you must have a PhD in molecular/cellular biology, genetics, biochemistry or bioengineering, with 1-3 years of CRISPR based gene editing experience. Deep understanding of various gene editing platforms and consistent track record of optimizing CRISPR-based gene editing is required. Demonstrated proficiency with primary human and/or murine cell engineering using ex-vivo CRISPR gene editing. Experience of working with different types of mammalian cells including primary cells. Experience with delivery techniques for CRISPR based gene editing ex-vivo (electroporation, LNP, viral mediated). Experience with large scale screening assays is definitely a plus.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

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