Scientist (Immuno-Oncology)

Location
Tarrytown, NY, United States
Posted
Oct 12, 2020
Ref
21012BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
The successful candidate will directly contribute to the development of novel antibody therapeutics to treat a variety of malignancies in patients. This candidate will join a dynamic, high-profile, and multidisciplinary team that studies an array of anti-tumor immunotherapies including checkpoint inhibitors. The scientist will be responsible for validating our expanding portfolio of antibodies that have been engineered to engage a variety of immune effector pathways, including co-stimulatory signaling. Specifically, this candidate will develop novel animal models to conduct complex in vivo and ex vivo animal tumor studies to test rational combinations of cancer therapeutics with the goal of advancing leads to the clinic. The qualified individual will have a strong background in one or more areas of tumor biology, immunology, oncology, and/or immuno-oncology. Ideal applicants will possess excellent interpersonal and communication skills, as this candidate will be expected to work productively in a collaborative, cross-functional team environment.

As a Scientist in Inflammation and Immunology, a typical day might include the following:

- Design, plan, and independently perform complex anti-tumor efficacy studies in mice including: cell culture, dosing (IV, SC, IP), and measuring tumors, as well as the dissection of immune organs for subsequent ex vivo analysis.
- Develop novel murine models to investigate combinatorial immuno-therapeutic strategies
- Design flow cytometry (FACS) panels and perform FACS analysis on human and murine cells, tumors, and tissues
- Synthesize results across experiments and programs in PowerPoint presentations and present to colleagues and senior management, including clinical and regulatory teams.
- Responsible for authoring documents to be published in regulatory filings, patent applications, external conference posters, and journal articles.
- Work successfully in cross-functional teams by contributing data and ideas
- This Scientist position comes with the potential to manage Research Associates

This role may be for you if:

- You are skilled in the design of complex studies to interrogate in vivo efficacy of novel therapies
- You have strong critical thinking and problem-solving abilities
- You have commitment to scientific excellence and furthering your knowledge in the filed
- You have proven interpersonal and written/oral communication skills

To be considered for this position you must have Ph.D, in Immunology, cancer biology, biochemistry, and at least 3 years of experience. We are looking with someone who can independently perform in vivo efficacy studies in both immunocompetent and immunocompromised mice (tumor implantation, monitoring tumor growth by caliper or bioluminescence (IVIS), and monitoring survival). Skilled in ex vivo and in vitro techniques, including the culture of human and mouse cells and the analysis of serum cytokine level. Skilled in development and design of FACS antibody panels and analysis of FACS data. Bioinfomatics and programming skills (eg. R, Python) are preferred but not required.

This position will require the individual to pass a physical before beginning employment.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.