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System Integration Engineer - Biotechnology/Scientist

Employer
DNA Script
Location
San Francisco, CA, United States
Start date
Oct 11, 2020

View more

Discipline
Science/R&D, Research, Laboratory
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay

Job Details

Become part of our Product Development team and help us to design and conduct feasibility studies investigating and optimizing the interactions among reagents, consumables, hardware and protocols. You will be able to use statistical methods to evaluate data, identify trends and make clear recommendations based on data. You will interface with a cross-functional project team to ensure alignment with design requirements and that the product meets approved quality standards. You will maintain detailed documentation throughout all phases of product development, and provide technical input for FMEAs, risk mitigation strategies and designs.

Responsibilities

• Assay characteristics of reagents and consumables, including both objective and performance criteria

• Troubleshoot hardware and software protocols and sources of variability derived from both reagents and consumables

• Formulate test batches of reagents for experimental use and performance characterization.

• Contribute to formulation of production lots of reagents following defined Work Instructions and completing batch records

• Perform acceptance tests on production batches of reagents and consumables

• Preparation of specific reagents and consumables for daily experimentation and performance characterization

• Analyze data using analytical tools (e.g., Excel, Python, R, ImageJ), documenting and presenting results to the team

• Create, track, monitor, and report metrics and key performance indicators for DNA Script instrument systems

• Perform system and subsystem verification and validation protocols

• Manage reagent stability study design, and execution. Investigate alternate materials to enhance reagent stability and/or improve system design/performance

• Troubleshoot and optimize fluidic dispense systems, thermal control systems and related subsystems. Develop and document acceptance / verification tests as required.

• Complete documentation to support testing procedures including data capture, forms, logbooks, and inventory batch records

• Define and develop performance-oriented feasibility studies for procedure improvements and newly implemented capabilities within the context of prototype development and improvement of finished products

• Execute and report the results of end-to-end experimental runs, including oligo design, run setup, observation of runs-in-progress, performance of a variety of molecular QC assays (qPCR, gel electrophoresis, NGS), data analysis and reporting of single data sets or trends across long term studies.

Experience

• BS in Biological Sciences or Engineering with 5+ years of experience in the Life Science and laboratory automation domain

• Strong skills in laboratory and system feasibility experimentation and Verification and Validation execution, Data Analysis, representation, and presentation, reagent formulation and GLP/GMP documentation. • Desire and ability to work in a small interdisciplinary team to develop new technologies at a rapid pace

Ideal Candidate will have

• Experience in regulated Life Science product/medical device development under design controls is preferred

• Knowledge of liquid handling and laboratory automation, microfluidics, molecular assay and QC techniques, and reagent and platform manufacturing techniques is preferred.

• Demonstrated problem-solving and troubleshooting skills along with strong verbal and written communications

• Organized and detail oriented

• Ability to work in a team environment

Miscellaneous
  • Job located in South San Francisco
  • Start date: Q3 2020
  • Contact: cdm@dnascript.co

Company

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system. 

To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners, T Rowe Price, Baillie Gifford and Eurazeo. 

DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense.

DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

Opportunity and Challenges 

We are looking to assemble a team of best-in-class, innovative and passionately eager people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences.
 

French office: 67 avenue de Fontainebleau, 94 270 Le Kremlin-Bicêtre

US Headquarters: 2001 Junipero Serra Blvd. Suite 400, Daly City, CA 94014, USA

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Company info
Website
Phone
650-457-0844
Location
2001 Junipero Serra Blvd. Suite 400
Daly City
CA
94014
United States

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