AbbVie

Scientist II, Genomic Technologies

Employer
AbbVie
Location
Lake County, IL, United States
Posted
Oct 10, 2020
Ref
2005910
Required Education
Masters Degree/MBA
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

AbbVie is making a significant push into Genomics and Genetics for drug discovery and development. In the past several years, we've made multiple investments in internal capabilities and external partnerships with leading academic groups and technology companies. In 2016 we created an internal research group, the AbbVie Genomics Research Center (GRC) within Discovery R&D. The GRC is a single organization that supports and drives genomics and genetics research across AbbVie R&D. The GRC has core capabilities and research efforts in Genomic Technologies, Functional Genomics, Computational Genomics, Human Disease Genetics, Pharmacogenetics, and has dedicated support for IT infrastructure. The core mission of the group is to apply genomics and genetics research to target discovery, target validation, translational research, and design and analysis of clinical trials. The GRC is seeking to hire a genomic technology scientist to support and drive existing genomic profiling pipelines and to also expand genomic profiling capabilities.

The GRC Genomic Technologies Team supports AbbVie preclinical and clinical research teams by applying genomic profiling technologies with the goal of improving the success rates for drug discovery and development. We apply genomic profiling technologies to identify and validate targets and biomarkers, improve understanding of preclinical models and candidate drug molecules, select/stratify patients and understand patient responses in AbbVie clinical trials. The successful candidate will be responsible for carrying out genomic profiling experiments and communicating results to stakeholders and collaborators and will also help drive efforts to expand genomic profiling capabilities to serve unmet needs.

Key Responsibilities:

  • Work with AbbVie Genomic Research Center (GRC) stakeholders and AbbVie therapeutic area (TA) scientists to meet the genomic profiling needs from active studies. Collaborate on experiment design, execution, and analysis to deliver high quality results under agreed upon timelines.
  • Process and perform QC analysis of NGS libraries derived from starting materials such as, whole blood, tissues and cells. Perform initial data QC and first pass analysis of results. Partner with bioinformatics specialists and disease area scientists to interpret results and design follow up experiments.
  • Operate and maintain genomic technology platforms within centralized technology group.
  • Effectively communicate with stakeholders, especially around troubleshooting and responding to changes in priorities and adjusting timelines.
  • Prepare written summaries of experimental results and verbally present at team meetings.
  • Stay current on rapidly evolving NGS genomic profiling workflows including: RNAseq, DNAseq, and single cell sequencing protocols . Contribute to technology development efforts as needed.


Qualifications

Qualifications:

  • MS in molecular biology, genomic sciences or a related field with 5+ years of experience, or BS with 8+ years of experience.
  • Demonstrated record of hands-on experience and deep technical knowledge of genomic profiling technologies with emphasis on next generation sequencing platforms and library preparation workflows including: WGS, WES, targeted DNAseq, RNAseq and single cell).
  • Experience being part of a centralized technology group is desirable. Industry experience is desired but willing to consider individuals with equivalent years of experience in academic or non-industry research settings.
  • Expert and detailed knowledge of genomic sample processing, sample QC, genomic profiling data QC and analytical methods.
  • Familiarity with LIMS, sample tracking, and workflow optimization.
  • High attention to detail, strong written and verbal communication skills, ability to work independently and as part of a team.
  • Ability to work in fast-paced, dynamic environment and to independently carry forward multiple projects in parallel.


Significant Work Activities
N/A
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.