Scientist - Computational Biology

South San Francisco, CA, US
Oct 10, 2020
Required Education
Bachelors Degree
Position Type
Full time
The Genome Analysis Unit (GAU) is seeking a talented computational biologist to join our team and further our mission of making biological discoveries that accelerate development within Discovery Research and Preclinical Development at Amgen. The position focuses on the application of bioinformatics expertise to the analysis and interpretation of large datasets to support ongoing drug development projects in close collaboration with project teams. These datasets include in vitro and in vivo assay results, RNA expression, genetics, and high value public resources. Additionally, the role will involve the creation of novel algorithms and analytical approaches that can be used to both identify new drug targets as well as predict the safety profile of our molecules and thus increase clinical success rates.

Position Responsibilities

Apply advanced techniques in bioinformatics, statistical analysis, and programming to biological problems across a wide range of human disease and drug safety areas at Amgen

Work with large internal and external biological data sets including Next Generation Sequencing (NGS) data (e.g. RNA-Seq, scRNA-Seq, WGS).

Interface directly with project teams and key stakeholders within Amgen to ensure the appropriate and timely inclusion of relevant datasets

Integrate work tightly with wet lab efforts within the GAU, Discovery Research and CBSS focused on predictive safety and target validation

Represent group internally and externally through presentations, publications, networks, collaborations and conferences to promote approaches and raise the profile of work within the team

Basic Qualifications

Doctorate degree


Master's degree and 4 years of scientific experience


Bachelor's degree and 6 years of scientific experience

Preferred Qualifications

Advanced degree in Bioinformatics, Biostatistics, Computer Science, Genomics

Hands-on experience in the fields of bioinformatics and genomics including working with various public and proprietary data repositories (e.g., TCGA, GTEx, dbGaP, Ensembl, UCSC genome browser, Array Studio), bioinformatics tools (e.g., BLAST, GATK, Cell Ranger, samtools, VEP), and statistical environments (e.g., R, S+, Matlab)

Experience with manipulation, interpretation, and innovative analysis (e.g. novel algorithm development) of large biological datasets, especially single-cell sequencing data

Research experience in the field of immuno-oncology, especially analyses for various immune cell subsets

Proficient in programming (e.g., Python, Java, C/C++) and working in a Unix/Linux environment; ability to develop customized bioinformatics tools

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.