Post Doctoral Fellow
- Employer
- Frederick National Laboratory for Cancer Research
- Location
- Frederick, MD, USA
- Start date
- Oct 7, 2020
View more
- Discipline
- Clinical, Clinical Data, Clinical Trials, Information Technology, Business/Data Analytics, Science/R&D, Biology, Immunology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- BioCapital
Job Details
The Clinical Services Program's primary mission is to perform sequential studies using samples obtained from patients with cancer, AIDS, chronic granulomatous disease or other diseases associated with immunologic dysfunction, as well as to monitor viral load in patients with HIV. The Vaccine, Immunity and Cancer Program investigates immune responses to vaccines in preclinical and clinical studies, with a focus on HPV and most recently on COVID-19.
The Vaccine, Immunity and Cancer Program is seeking a highly motivated and talented individual with strong background in cell and molecular biology, cancer biology, and genomics. Knowledge and experience in mouse models, immunology and vaccinology will be a plus. The selected individual will focus on how a disrupted post-translational modification process (SUMOylaton and deSUMOylation) contributes to cancer initiation and progression and collaborate with others on identifying liquid biomarkers for clinical trial monitoring and early detection of cancers. The project will involve both in vitro and in vivo work.
KEY ROLES/RESPONSIBILITIES
Responsibilities include, but are not limited to, the following:
- Formulate hypotheses, prepare protocols and reports, execute experiments, record experimental data, and interpret experimental results.
- Investigate the mechanisms by which SUMO isopeptidases of the SENP family promote cancer development
- Establish sensitive quantitative assays/methods in the emerging areas of liquid biomarkers for clinical trial monitoring
- Present research findings at local and national conferences and in journal publications
BASIC QUALIFICATIONS
- Possession of a Ph.D degree from an accredited college or university according to the Council for Higher Education Accreditation. Foreign degrees must be evaluated for U.S. equivalency
- Experience in biomedical research, such as cell and molecular biology, cancer biology, genomics, or biomarker-related field
- Independently design and execute the experiments, and evaluate and analyze experimental data
- Ability to troubleshoot assays and experiments independently
- Strong organizational skills with the ability to prioritize multiple tasks and projects
- Excellent verbal and written communication skills
PREFERRED QUALIFICATIONS
- A record of outstanding research productivity
- Proficient in cell and molecular biology techniques, immunoassays and next generation sequencing (e.g. cell culture, Western blot, PCR, cloning, gene knockdown or overexpression, flow cytometry, sequencing library preparation, etc.)
- Sequencing data analysis using commercial software
- Experience in preclinical research using genetically engineered mouse models
- Experience in liquid biomarker discovery
JOB HAZARDS
- This position is subject to working with or have potential for exposure to animal(s) and/or animal material(s)
- This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
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Company
A rewarding career with global impact
Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.
Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.
We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.
Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.
Discover why joining the Frederick National Laboratory team could be the most important career step you take
- Website
- https://frederick.cancer.gov/
- Phone
- 301-846-1000
- Location
-
8560 Progress Drive
Frederick
MD
21701
US
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