Senior Scientist, Immune Oncology 高级科学家

Location
San Francisco, CA, United States
Posted
Oct 02, 2020
Ref
193471652
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time
Zai Lab is seeking a cancer immunologist to drive validation of novel targets and explore activity, mechanism of action, and rational combinations for preclinical and clinical therapeutic molecules. The successful candidate will be a member of a fast-paced and interactive research team contributing to the discovery and development of novel therapeutics.

Organizational Relationships:

The Sr Scientist reports to the Head of Discovery Biology and Translational Medicine, and collaborates with Medicinal Chemistry, in vivo Pharmacology, and DMPK.

Responsibilities:

- Develop, design, execute and validate various in vitro and ex vivo model systems/assays to drive preclinical drug discovery and define mechanism of action of therapeutic molecules in the area of immune oncology

- Evaluate and characterize pharmacological responses to novel compounds in variety of in vitro and ex-vivo model systems (e.g. effects on composition/functions of the tumor microenvironment)

- Perform day-to-day laboratory bench work and present scientific findings/results internally and externally

- Provide experimental support and immunology expertise for validation of targets and drug discovery and development projects

- Provide immunology expertise for the design of preclinical biomarker studies (pharmacodynamic, response, etc.)

- Search, evaluate and adopt the latest methodology/ technology to advance preclinical immuno-oncology research

- Execute experiments and scientific tasks with a high level of independence and scientific rigor

- Manage internal and external (academic and contract research organizations) resources to deliver quality data in an efficient manner

- Contribute to building a culture that embraces continuous learning and improvement and disease biology expertise; take a proactive role in scientific development and personal growth

Qualifications:

- Ph.D.in immunology or cancer immunology, with relevant post-doctoral research experience in the field of immuno-oncology

- Demonstrated proficiency in broad range of experimental techniques

- Ability to work with minimum supervision in generating experimental hypothesis, designing and executing experiments, data analysis and interpretation.

- Proficiency in multi-color flow-cytometry platforms and multiplex Luminex/MSD ELISA is required.

- Experience in immune cell profiling and in vitro manipulations such as, but not limited to, immune cell differentiation, activation and suppression, is required

- Expertise in CRISPR- and/or shRNA mediated gene editing

- Experience with gene expression analysis, western blot, immuno-fluorescence, IHC is preferred

- Strong communication skills

- Ability to work collaboratively in a cross-functional team setting

- Strong track record of productivity, as evidenced by driving project forward and robust publications

If you are interested in this position, please send an email with your resume to talent_us@zailaboratory.com