Senior Scientist, In vivo Gene Therapy Research

Location
Cambridge
Posted
Sep 30, 2020
Ref
4828145002
Hotbed
Genetown
Required Education
Doctorate/PHD/MD
Position Type
Full time
JOB PURPOSE

Sana Biotechnology is looking to expand our team with hard-working individuals who believe in the potential of cells as engineered medicines. We are looking for enthusiastic scientists to forward our gene therapy platform. The candidate will be working in vibrant research environment with cross-functional connections to technical operations and pharmacology groups. Candidates should have the vision to do creative things and the determination to execute that vision, and will both manage contract research organizations (CROs) and direct reports as well as participate in lab activities.

This position will report directly to the director of the In Vivo Research group within the department of Gene Therapy. The Senior Scientist will have three primary responsibilities: (1) to design and execute in vivo studies to support gene therapy research programs at Sana, (2) support cell and tissue preparation and analysis work related to in vivo studies, and (3) to support needs across the Gene Therapy organization. The position will also require close communication and collaboration with research groups at Sana outside of the Gene Therapy organization.

DUTIES & RESPONSIBILITIES
  • Work closely with the Director to plan and execute in vivo studies in-house and at CROs
  • Provide strategic input, with Director, to development of the Gene Therapy platform
  • Design, execute and analyze in vivo studies in support of Sana's novel Gene Therapy platform
  • Tissue collection and processing for downstream assays such as flow cytometry, histology and molecular work
  • Support in vitro work (e.g. cell culture) to enable in vivo studies
  • Data recording, analysis and reporting using proper software (e.g. Prism, FlowJo) and electronic notebook
  • Presentation of data to the team
  • Participate in creating a collaborative, rewarding work environment

QUALIFICATIONS

Required Qualifications
  • Experience (PhD/Post-doctoral 2+ years or MS 7+ years) with development of preclinical animal models supporting gene therapy in an industry or academic setting
  • Post-graduate degree in Cell Biology, Regenerative Medicine, Bioengineering, Pathology or related fields and extensive hands-on research experience in preclinical disease models.
  • Extensive experience in managing and working with Contract Research Organizations (CROs)
  • Experience in working with mice: handling, injections (IV, IP, SC), bleeding, tissue harvest and writing animal protocols
  • Proficiency with standard molecular biology and cell biology techniques: RNA isolation and reverse-transcription, qPCR, mammalian cell culture, staining for Flow Cytometry and Lentivirus production and transduction
  • Demonstrated experience with relevant software: Microsoft Word, Excel, PowerPoint, Graphpad Prism, FlowJo software
  • Experience in developing in vitro and in vivo assays
  • Proven ability to troubleshoot technical and scientific issues
  • Strong interpersonal skills and adaptable communication style
  • Strong organizational, record keeping, and data documentation skills
  • Excellent oral and written communication skills, attention to detail and data quality, and experience working on diverse collaborative teams

Preferred Qualifications
  • Expertise in T cell immunology and/or Hematopoietic Stem Cells
  • Expertise in delivery pharmacology, specifically pharmacokinetics