Senior Research Associate, AAV Process Development

Cambridge, MA, United States
Sep 27, 2020
Required Education
Bachelors Degree
Position Type
Full time
Our mission:

Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Intellia is seeking a skilled and motivated Senior Research Associate to support AAV process development and production in the Technical Operations group. The ideal applicant will be experienced and capable in HEK culture and transfection, AAV production processes and characterization assays. Experience with bioreactor suspension culture and scalable downstream processes under GMP is a plus. Team work, versatility, and strong problem solving/analytical skills are required.

    • AAV upstream process development and transfection optimization.
    • Support of AAV production for R&D.
    • Develop and perform pre-clinical scale up production processes based on QbD.
    • Perform analytical methods for the evaluation of critical AAV product attributes.
    • Collaborative integration within Tech Ops.
    • Develop SOPs and assist in technology transfers to CROs and strategic partners.
    • Provide high quality data and ELN documentation to drive decision making in the CMC team.
    • Communicate development results and production schedules with internal teams.
    • Operate and maintain multiple laboratory instruments.
    • Cell culture maintenance and analysis.

    • Bachelor's Degree in Molecular Biology, Virology, or Biochemical Engineering with at least 2-3 years of hands on industry experience, or MS with 1-2 years of industry experience.
    • Proficiency with relevant cell culture, purification and analytical techniques.
    • Experience with chromatography purification and TFF systems with biomolecules/virus
    • Experience in bioreactor cell culture and purification process development scale up for GMP production.
    • Experience with assay development is a plus (e.g. CE-SDS, ddPCR, ELISA).
    • Organized, detail-oriented, and a self-starter who continuously seeks innovative solutions.
    • Excellent verbal and written communication skills.


What Intellia Stands For:

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.

- Explore because we seek new ways to tackle disease. Explore with unbounded from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.

- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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