Associate Scientist, Screening and NGS Platform Development

Cambridge, MA, United States
Sep 24, 2020
Required Education
Masters Degree/MBA
Position Type
Full time
Our mission:

Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.


Intellia is seeking a highly skilled and motivated associate scientist to join our dynamic team. The successful candidate will be a part of the Screening and NGS Platform Development (SNPD) team, focused on high throughput screening and assay development. We are a fast paced, high energy and closely collaborative group that strives to deliver superior data under tight timelines. Applicants should have experience working in a high throughput environment following SOPs. Familiarity with NGS, genetic perturbation, primary cell culture and complex data analysis strongly preferred. Familiarity with liquid handling robots is preferred. Applicants should have exceptional time management and communication skills (both written and oral) coupled with a strong attention to detail.

    • Conduct standard cell culture support including maintaining and plating of primary and immortalized cell lines
    • Following SOPs to support high throughput in vitro CRISPR screening
    • Perform in vitro high throughput process optimization
    • Perform optimization of transfection conditions for DNA/RNA/lipids
    • Screening of guide RNA sequences via transient transfection invitro for lead identification
    • Design, implement, troubleshoot and modify experiments to reach desired goals
    • Record and communicate findings accurately and professionally
    • Conduct experiments, independently and in collaboration with colleagues to achieve gene editing in cell lines and primary cells in support of project goals
    • Assist teammates with experimental design, execution, interpretation and presentation of data

    • MS or BS in Molecular Biology or a related discipline with 4+ years of relevant experience, preferably in an industrial drug discovery setting
    • Experience with maintaining and plating a variety of immortalized and primary cell lines.
    • Experience with CRISPR or RNAi screening
    • High throughput automation in-vitro screening
    • Experience handling high volume sample output
    • Liquid handling/robotics experience (Hamilton platform preferred)
    • Experience with qPCR, MSD and ELISA is a plus
    • Knowledge of NGS, interpretation of sequencing data a plus
    • Experience with primary hepatocytes, T-cells or HSCs a plus


What Intellia Stands For:

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.

- Explore because we seek new ways to tackle disease. Explore with unbounded from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.

- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Intellia's web-based application process is managed through Lever. Information submitted through application forms is collected by Lever and subject to Lever's privacy policy .