Scientist I/II

About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

We are currently seeking a highly motivated Scientist/Engineer to join our downstream group in the Manufacturing Sciences department at AbbVie Bioresearch Center based in Worcester, MA. As part of the Manufacturing Sciences organization, our group leads the downstream process validation, implementation, optimization, and global technical support activities for late-stage and commercial manufacturing of therapeutic proteins and antibody-drug-conjugates (ADCs) for AbbVie. We also provide manufacturing support and author regulatory filing CMC sections. The candidate should have experience and a comprehensive knowledge of process characterization and process performance qualification activities.

Key Responsibilities:

• Design, execute, and interpret results of lab-scale process characterization and process optimization activities
• Design and document results of process performance qualification activities
• Identify, evaluate, and develop innovative technologies within the field of downstream processing to improve process efficiency, robustness, and product quality
• Lead technology and process transfer activities to pilot scale and GMP plants
• Solve technical issues/troubleshooting and support GMP manufacturing; provide on-floor manufacturing support at AbbVie and at TPM sites
• Participate in cross-functional teams and author/review technical protocols, reports, memos, and validation documents
• Interact with cross-functional groups (e.g., R&D, Manufacturing, Engineering, Quality, Regulatory)
• Act as a mentor for junior scientists
• Effectively organize and present scientific plans and data

Qualifications

Basic Requirements:

• B.S. or M.S. in Chemical or Biochemical Engineering, Biochemistry, or related field with typically 6+ years (BS) or 3-5 years (MS) of relevant pharmaceutical industry experience
• Laboratory and/or manufacturing scale experience with typical protein purification and/or ADC unit operations (e.g., centrifugation, filtration, chromatography, UF/DF)
• Outstanding record of accomplishment in areas of purification bioprocess development, improvement, and validation
• Strong written and oral communication skills and the ability to contribute in a multi-disciplinary environment are essential
• Interact well with diverse groups across functional areas and maintain strong working relationships with internal, global, and external collaborators
• Demonstrated problem-solving skills and capability to overcome complex issues
• Demonstrated success in coordinating and executing important projects to achieve business unit goals within timelines
• Demonstrated ability to learn, understand, and implement new experimental techniques

Preferred Skills:

• Chromatography workstation experience (programming and running), esp. w/ AKTA
• Understanding of antibody-drug conjugation chemistry; experience with relevant analytical techniques (e.g. SoloVPE, HPLC)
• Understanding and experience with statistical experimental design (DOE) and statistical programs (e.g. JMP, Minitab)

Significant Work Activities
N/A
Travel
Yes, 5 % of the Time
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.