Frederick National Laboratory for Cancer Research

Scientist I

Location
Frederick, MD, USA
Posted
Sep 24, 2020
Ref
req1395
Hotbed
BioCapital
Required Education
Doctorate/PHD/MD
Position Type
Full time
The Clinical Services Program's primary mission is to perform sequential studies using samples obtained from patients with cancer, AIDS, chronic granulomatous disease or other diseases associated with immunologic dysfunction, as well as to monitor viral load in patients with HIV.

The Vaccine, Immunity and Cancer Program investigates immune responses to vaccines in preclinical and clinical studies, with a focus on HPV.

KEY ROLES/RESPONSIBILITIES

The Vaccine, Immunity and Cancer Program is looking for a Scientist I to lead serology high-throughput testing and Research and Development projects related to COVID-19.

The Scientist will be responsible for leading assay development and validation projects as well as studies evaluating immune responses to infection, vaccines and cancer.

Specific duties will include:
  • Provide scientific project management support
  • Strong scientific background on immunology, virology and serology
  • Serve as scientific/technical lead for the assigned projects
  • Serve as scientific/technical lead for assay development, assay validation and high throughput testing
  • Plan and work independently with minimal supervision
  • Perform technical development and qualification /validation of various immunological assays including cell-based viral neutralization assays, ELISAs, multiplex assays
  • Assay Development (including experimental design and troubleshooting), optimization and validation of immune assays
  • Previous experience in conducting assay validation, including protocol and report writing
  • Design, implement, execute assigned projects with minimal supervision
  • Prepare documentation associated with project/objectives including technical reports, SOPs, project specific protocols and reports
  • Prepare manuscripts and scientific presentations
  • Ensure laboratory procedures and testing is compliant with internal requirements and quality system
  • Work with automated systems, such as robotics, system integration and software programming
  • Oversight of critical reagent and assays standard production
  • Oversight of equipment qualification and validation relevant to the various assays
  • Analyze data and present findings at meetings

BASIC QUALIFICATIONS
  • Possession of a PhD in immunology, virology or a related biomedical field from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for U.S. equivalency
  • Extensive experience in ELISA, viral neutralization assays and mammalian cell culture required
  • Experience in development, qualification & validation of relevant immune assays
  • Experience in conducting assay validation, including protocol and report writing
  • Understanding of GCLP requirements and other FDA regulatory requirements for immunological testing
  • Strong Computer skills and experience with relevant software such as Softmax, Excel, PowerPoint, ability to analyze data using statistical tools (e.g. JMP, Prism)

PREFERRED QUALIFICATIONS
  • Regulatory knowledge pertinent to standards GCLP, CLIA or FDA guidelines for clinical assays
  • Familiarity with diagnostics and clinical trials
  • Project Management Professional (PMP) certification

EXPECTED COMPETENCIES
  • In‐depth understanding of immunology, immune assays, diagnostics, vaccines and clinical research
  • Excellent communication skills (written and oral)
  • Ability to work effectively in a team‐oriented environment
  • Ability to identify and solve complex problems
  • Strong organizational and multitasking skills
  • Strong Computer skills and experience with relevant software such as Softmax, Excel, PowerPoint, ability to analyze data using statistical tools (e.g. JMP, Prism)

JOB HAZARDS
  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations


Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

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