Senior Research Associate, Translational Research - Immuno-Oncology Cell Therapy

Seattle, WA, United States
Sep 24, 2020
Required Education
Associate Degree
Position Type
Full time
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Bristol-Myers Squibb is a global Biopharma company committed to a single mission to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

The Late-Stage translational research team in the Immuno-Oncology Cell Therapy Thematic Research Center has an opening for a highly motivated and creative Research Associate/ Senior Research Associate to conduct laboratory-based experiments to further the understanding of clinical-stage assets for the treatment of cancer. The successful candidate will work closely with the supervisor to contribute to mechanism of action and drug combination studies that would enable deeper durable responses for patients. The candidate must be familiar with mammalian cell culture and setting up in vitro functional assays to measure product functional attributes such as proliferation, cytokine production, phenotypic analysis and cytotoxic activity. Prior experience with clinical samples, human T cells and/or evaluation of CAR-T is preferred. Flow cytometry experience is highly preferable. In addition, this position will work with senior researchers to execute studies, analyze data and communicate timely results. This position is ideal for an innovative, self-driven scientist who is forthcoming; willing to learn; and is passionate about cell therapy in a fast-paced, collaborative environment.

Primary responsibilities

  • Interrogation of primary human material; cell handling, setup and maintenance of tissue culture studies
  • CAR T cell phenotypic analysis using flow cytometry. In vitro functional evaluation using T cell/Tumor co-culture assays
  • Cytotoxic activity using IncuCyte
  • Cytokine assessments using MSD and intracellular cytokine production by flow cytometry
  • Collaborating with scientists and other researchers to design, perform and optimize in vitro experiments
  • Maintaining notebooks with detailed documentation of protocols, study designs and results
  • Perform data analysis and interpretation
  • Organize findings for effective communication to supervisor, colleagues as well as at external conferences

Basic Qualifications
Research Associate: B.S. in biological science, immunology or related discipline with 2+ years of relevant work experience or M.S. degree
  • Senior Research Associate: B.S. in biological science, immunology or related discipline with 4+ years of relevant work experience or M.S. with 2+ years of work experience
  • 2+ years of immunology laboratory experience with in-vitro cell based assays
  • Experience with primary cell culture
  • Ability to analyze, interpret, and present scientific data in a clear manner
  • Strong organization, time management and problem-solving skills with attention to detail
  • Desire and ability to expand skill-sets at the bench and knowledge-base through independent reading and seeking out information from colleagues and collaborators

Preferred Qualifications
Working knowledge of clinical samples, human T-cells and functional assays to evaluate CAR T cells
  • Experience with high-parameter FACS (10-15+ colors)
  • Prior experience writing method development protocols
  • Able to recognize potential problems and recommend/develop appropriate solutions

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.