Senior Scientist, T Cell Biologist

Location
Cambridge, MA, United States
Posted
Sep 23, 2020
Ref
1812772552
Hotbed
Genetown
Required Education
Doctorate/PHD/MD
Position Type
Full time
Our mission:

Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Would you like to work in a company that is energetic, exciting, and fun? If so, Intellia may be the place for you! An exciting opportunity for an immunologist is available in our Gene Editing group; where we leverage top-notch CRISPR technology to fully unleash the power of cell-based therapy for Autoimmune and Immuno-Oncology indications. The ideal candidate would be versed in T cell biology, a strong expertise in experimental assays related to T cell molecular and cell biology. Experience with in vivo models would be a plus.

GENERAL RESPONSIBILITIES:
    • Design, implement, and troubleshoot experiments, both independently and in collaboration with colleagues, to reach desired goals
    • Establish in vitro and in vivo assays to support T cell projects
    • Communicate research and development findings with internal and external teams/partners in a clear and concise manner
    • Diligent and timely documentation of experiments in ELN and reports


REQUIRED SKILLS:
    • Hands-on experience with handling human T cells, T cell isolation techniques, activation and transduction of T cells, T cell expansion, multicolor flow cytometry for T cell characterization
    • Experience with expansion of engineered T cells
    • Strong background in human T cell biology and T cell-based assays, including proliferation assays, tetramer staining, cytotoxicity assays, intracellular flow cytometry staining or cytokine profiling assays by ELISA or MSD, cell activation marker analysis
    • Development and optimization of purification methods for edited T cells
    • Some experience with gene editing such as gene deletions and insertions
    • General molecular biology techniques


REQUIRED SKILLS:
    • Hands-on experience with handling human T cells, T cell isolation techniques, activation and transduction of T cells, T cell expansion, multicolor flow cytometry for T cell characterization
    • Experience with expansion of engineered T cells
    • Strong background in human T cell biology and T cell-based assays, including proliferation assays, tetramer staining, cytotoxicity assays, intracellular flow cytometry staining or cytokine profiling assays by ELISA or MSD, cell activation marker analysis
    • Development and optimization of purification methods for edited T cells
    • Some experience with gene editing such as gene deletions and insertions
    • General molecular biology techniques
    • Experience with T cell engineering, such as CAR-T or transgenic TCR T cells, would be a plus.


QUALIFICATIONS:
    • PhD in immunology, cell biology or related field with 3-6 years postdoctoral experience, preferably with some industry experience or Post PhD 2-3 years of industry experience.
    • Excellent interpersonal skills and ability to work efficiently and productively in a highly dynamic, scientifically rigorous, and fast-paced environment
    • Ability to optimize complex protocols and assays to meet desired outcome
    • Ability to quickly adapt and learn when faced with new challenges
    • Strong motivation to deliver solid scientific results and focus on delivering on goals and timelines
    • Strong organizational skills and the ability to handle multiple projects in parallel
    • Effective verbal and written communication skills
    • Strong problem-solving and analytical skills


#LI-DG1

What Intellia Stands For:

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.

- Explore because we seek new ways to tackle disease. Explore with unbounded minds...free from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.

- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Intellia's web-based application process is managed through Lever. Information submitted through application forms is collected by Lever and subject to Lever's privacy policy .