Scientist, Immune CAR Cell Therapy

South San Francisco, California, United States
Sep 23, 2020
Biotech Bay
Required Education
Position Type
Full time
Thank you for your interest in a career at Senti Biosciences. We are passionate about developing cell therapies with the ability to outsmart cancer and other complex diseases. We find purpose and meaning in knowing that our efforts will soon improve the lives of patients and their families. With science as our foundation and empathy as our key guiding principle, colleagues become friends, managers become mentors, and with time, cancer becomes history.

Our team is seeking a talented, and driven Scientist to develop and evaluate gene circuits for the generation of regulated cell therapies to address current challenges in solid tumors.

The successful candidate must be comfortable designing and performing immune cell-based assays independently and working collaboratively across various project teams to meet deadline-dependent milestones. Prior experience with NK cells and other immune cell handling, cell co-culture experiments, and functional assays is required.

Most of all, you are curious, bold, detail-orientated, and eager to be part of a positive work environment with other researchers to develop much needed novel cell therapies targeting cancer.

    • Design and perform immunology phenotypic and functional assays such as cell proliferation, cytoxicity, Luminex, multi-color flow cytometry, etc.
    • Stay current with the relevant scientific literature, and participate in ideation and decision-making meetings
    • Write SOP, maintain detailed electronic lab records, and perform data analysis.
    • Collaborate with your colleagues at Senti by coordinating with other group members and research teams to troubleshoot problems, develop new assays, and support cross-functional projects
    • Provide expert support for experiment design and assay development to the broader scientific team

    • PhD or equivalent with expertise in Cell Biology, immunoncology, or similar.
    • Minimum of 5 years of independent research experience in a biology laboratory setting; industry experience is a plus.
    • Excellent understanding of NK cell biology
    • Hands-on proficiency with NK cell culture, engineering and phenotypic and functional assays, including cell-based assays measuring cell proliferation, cytotoxicity, and cytokine production.
    • Experience with multicolor flow cytometry and FlowJo-based data analysis.
    • Ability to quickly adapt to new research areas and implement new techniques with minimal supervision.
    • Demonstrated ability to work independently and as part of a multi-functional team.
    • Preferred additional qualifications include experience with chimeric antigen receptors (CARs), lentivirus generation, hematopoietic cell transduction, ELISA/Luminex, Incucyte, and understanding of assays related to the evaluation of integration and construct function.

Salary & Benefits
    • Competitive compensation package and title commensurate with qualifications and experience in the South San Francisco Biotech market including:
    • - Generous 401k instant-vesting employer match
    • - Healthy snacks and daily lunch program
    • - Medical, Dental, Vision, Life & Disability benefits
    • - EAP, Concierge Service, Recognition Awards and Career Development Opportunities
    • Significant career growth opportunity as the company develops

Senti Bio is the next generation therapeutics company that designs gene circuits and programs cells for tremendous therapeutic value. Our mission is to engineer an entirely new class of medicine that will transform people's lives by curing the most challenging diseases. We are proud to count NEA, 8VC, Amgen Ventures, Pear Ventures, Lux Capital, Menlo Ventures, Allen & Company, Nest.Bio , Omega Funds, Goodman Capital, and LifeForce Capital among their investors. Senti Bio is based in South San Francisco, CA, USA.